URB1/YKL014C Summary Help

URB1 BASIC INFORMATION

Standard Name URB1 1
Systematic Name YKL014C
Alias NPA1
Feature Type ORF, Verified
Description Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit (1, 2, 3)
Name Description Unhealthy Ribosome Biogenesis 1
GO Annotations All URB1 GO evidence and references
    View Computational GO annotations for URB1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All URB1 Phenotype details and references
Classical genetics
repressible
Large-scale survey
null
Interactions URB1 All interactions details and references
106 total interaction(s) for 85 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 94
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1
Genetic Interactions
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 8
  • Synthetic Lethality: 1
Sequence Information
ChrXI:416556 to 411262 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Last Update Coordinates: 2005-12-15 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..5295 416556..411262 2005-12-15 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001497

URB1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for URB1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for URB1]

1) Mnaimneh S, et al.  (2004) Exploration of essential gene functions via titratable promoter alleles. Cell 118(1):31-44
2) Rosado IV and de la Cruz J  (2004) Npa1p is an essential trans-acting factor required for an early step in the assembly of 60S ribosomal subunits in Saccharomyces cerevisiae. RNA 10(7):1073-83
3) Dez C, et al.  (2004) Npa1p, a component of very early pre-60S ribosomal particles, associates with a subset of small nucleolar RNPs required for peptidyl transferase center modification. Mol Cell Biol 24(14):6324-37