PRP40/YKL012W Summary

PRP40 BASIC INFORMATION

Standard Name	PRP40
Systematic Name	YKL012W
Feature Type	ORF, Verified
Description	U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex (1)
Name Description	Pre-mRNA Processing

GO Annotations	All PRP40 GO evidence and references
	View Computational GO annotations for PRP40
Molecular Function
Manually curated	RNA binding (IDA)
Biological Process
Manually curated	nuclear mRNA splicing, via spliceosome (IDA)
Cellular Component
Manually curated	nucleus (IMP) U1 snRNP (IDA) U2-type prespliceosome (IDA)

Mutant Phenotype	All PRP40 Phenotype details and references
Large-scale survey
conditional	heat sensitivity: increased
null	inviable

Interactions	PRP40 All interactions details and references
	103 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-MS: 76 Affinity Capture-RNA: 1 Affinity Capture-Western: 6 Biochemical Activity: 2 Co-purification: 1 Reconstituted Complex: 2 Two-hybrid: 10
Genetic Interactions	Phenotypic Suppression: 1 Synthetic Growth Defect: 1 Synthetic Lethality: 3

Sequence Information

ChrXI:417953 to 419704 | |

Last Update

Coordinates: 2005-12-15 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1752	417953..419704	2005-12-15	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001495

PRP40 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PRP40

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PRP40]

1)	Abovich N and Rosbash M (1997) Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals. Cell 89(3):403-12

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