MRT4/YKL009W Summary Help

Standard Name MRT4 1
Systematic Name YKL009W
Feature Type ORF, Verified
Description Protein involved in mRNA turnover and ribosome assembly; required at post-transcriptional step for efficient retrotransposition; localizes to the nucleolus (1, 2, 3, 4)
Name Description mRNA Turnover 4 1
Chromosomal Location
ChrXI:426242 to 426952 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All MRT4 GO evidence and references
  View Computational GO annotations for MRT4
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 3 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
repressible
Resources
323 total interaction(s) for 227 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 91
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 98
  • Co-fractionation: 2

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 62
  • Phenotypic Enhancement: 1
  • Positive Genetic: 52
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 3
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 236
Molecular Weight (Da) 27,058
Isoelectric Point (pI) 9.05
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrXI:426242 to 426952 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..711 426242..426952 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001492
References cited on this page View Complete Literature Guide for MRT4
1) Zuk D, et al.  (1999) Temperature-sensitive mutations in the Saccharomyces cerevisiae MRT4, GRC5, SLA2 and THS1 genes result in defects in mRNA turnover. Genetics 153(1):35-47
2) Harnpicharnchai P, et al.  (2001) Composition and functional characterization of yeast 66S ribosome assembly intermediates. Mol Cell 8(3):505-15
3) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4) Risler JK, et al.  (2012) Host co-factors of the retrovirus-like transposon Ty1. Mob DNA 3(1):12