DSN1/YIR010W Summary

DSN1 BASIC INFORMATION

Standard Name	DSN1
Systematic Name	YIR010W
Feature Type	ORF, Verified
Description	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation (1, 2)
Name Description	Dosage Suppressor of NNF1 1

GO Annotations	All DSN1 GO evidence and references
	View Computational GO annotations for DSN1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chromosome segregation (IDA)
Cellular Component
Manually curated	kinetochore (IDA) nuclear MIS12/MIND type complex (IDA) spindle pole (IDA)

Mutant Phenotype	All DSN1 Phenotype details and references
Classical genetics
conditional	chromosome segregation: abnormal heat sensitivity: increased
Large-scale survey
null	inviable
repressible	cell cycle progression in G2 phase: abnormal

Interactions	DSN1 All interactions details and references
	53 total interaction(s) for 21 unique genes/features.
Physical Interactions	Affinity Capture-MS: 33 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Co-fractionation: 1 Two-hybrid: 7
Genetic Interactions	Dosage Rescue: 2

Sequence Information

ChrIX:375428 to 377158 | |

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1731	375428..377158	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001449

DSN1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for DSN1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for DSN1]

1)	Euskirchen GM (2002) Nnf1p, Dsn1p, Mtw1p, and Nsl1p: a new group of proteins important for chromosome segregation in Saccharomyces cerevisiae. Eukaryot Cell 1(2):229-40
2)	De Wulf P, et al. (2003) Hierarchical assembly of the budding yeast kinetochore from multiple subcomplexes. Genes Dev 17(23):2902-21

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