MSL1/YIR009W Summary Help

MSL1 BASIC INFORMATION

Standard Name MSL1
Systematic Name YIR009W
Alias YIB9
Feature Type ORF, Verified
Description U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members (1, 2, 3)
Also known as: YIB9w
Name Description MUD Synthetic Lethal 2
GO Annotations All MSL1 GO evidence and references
    View Computational GO annotations for MSL1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All MSL1 Phenotype details and references
Large-scale survey
null
Interactions MSL1 All interactions details and references
73 total interaction(s) for 58 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 21
  • Affinity Capture-Western: 2
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 21
Genetic Interactions
  • Dosage Rescue: 3
  • Phenotypic Enhancement: 7
  • Synthetic Growth Defect: 10
  • Synthetic Lethality: 6
  • Synthetic Rescue: 1
Sequence Information
ChrIX:374522 to 374857 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..336 374522..374857 1994-12-10 1994-12-10
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001448

MSL1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for MSL1

NOMENCLATURE CONFLICT NOTE

NameRelevanceDescription
NAM2Nomenclature conflictMSL1 has been used in the literature to refer to both NAM2/YLR382C (Tzagoloff, A. et al. (1988) J. Biol. Chem. 263:850; PMID:2826465), which encodes a mitochondrial leucyl tRNA synthetase, and MSL1/YIR009W (Tang, J. et al. (1996) Mol. Cell. Biol. 16:2787; PMID:8649387), which encodes the U2 small nuclear ribonucleoprotein particle B" protein.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MSL1]

1) Caspary F and Seraphin B  (1998) The yeast U2A'/U2B complex is required for pre-spliceosome formation. EMBO J 17(21):6348-58
2) Tang J, et al.  (1996) Identification and characterization of a yeast gene encoding the U2 small nuclear ribonucleoprotein particle B" protein. Mol Cell Biol 16(6):2787-95
3) Stevens SW, et al.  (2002) Composition and functional characterization of the yeast spliceosomal penta-snRNP. Mol Cell 9(1):31-44