PAN1/YIR006C Summary

PAN1 BASIC INFORMATION

Standard Name	PAN1
Systematic Name	YIR006C
Alias	MDP3 , MIP3 , DIM2 1
Feature Type	ORF, Verified
Description	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; previously thought to be a subunit of poly(A) ribonuclease (1, 2, 3)
Name Description	Poly(A)-binding protein-dependent poly(A) riboNuclease 4

GO Annotations	All PAN1 GO evidence and references
	View Computational GO annotations for PAN1
Molecular Function
Manually curated	protein binding, bridging (IPI)
Biological Process
Manually curated	actin cortical patch assembly (IMP) axial cellular bud site selection (IMP) bipolar cellular bud site selection (IMP) cytokinesis (IMP) endocytosis (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA) cytoplasm (IDA) nucleus (IDA)
High-throughput	mating projection tip (IDA) plasma membrane (IDA)

Mutant Phenotype	All PAN1 Phenotype details and references
Classical genetics
conditional	axial budding pattern: decreased rate bipolar budding pattern: decreased rate Clc1p distribution: abnormal
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable

Interactions	PAN1 All interactions details and references
	99 total interaction(s) for 37 unique genes/features.
Physical Interactions	Affinity Capture-MS: 5 Affinity Capture-RNA: 1 Affinity Capture-Western: 17 Biochemical Activity: 7 Reconstituted Complex: 8 Two-hybrid: 20
Genetic Interactions	Dosage Rescue: 2 Phenotypic Enhancement: 6 Phenotypic Suppression: 3 Synthetic Growth Defect: 7 Synthetic Lethality: 19 Synthetic Rescue: 4

Sequence Information

ChrIX:369905 to 365463 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..4443	369905..365463	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001445

PAN1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PAN1

NOMENCLATURE CONFLICT NOTE

Name	Relevance	Description
PNO1	Nomenclature conflict	Both PAN1/YIR006C and PNO1/YOR145C have been referred to as DIM2.

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PAN1]

1)	Wendland B, et al. (1996) A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol 135(6 Pt 1):1485-500
2)	Tang HY and Cai M (1996) The EH-domain-containing protein Pan1 is required for normal organization of the actin cytoskeleton in Saccharomyces cerevisiae. Mol Cell Biol 16(9):4897-914
3)	Zeng G, et al. (2001) Regulation of yeast actin cytoskeleton-regulatory complex Pan1p/Sla1p/End3p by serine/threonine kinase Prk1p. Mol Biol Cell 12(12):3759-72
4)	Sachs AB and Deardorff JA (1992) Translation initiation requires the PAB-dependent poly(A) ribonuclease in yeast. Cell 70(6):961-73

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