Standard Name	PAN1 (see Nomenclature conflict Note)
Systematic Name	YIR006C
Alias	MDP3 , MIP3 , DIM2 1
Feature Type	ORF, Verified
Description	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously thought to be a subunit of poly(A) ribonuclease (1, 2, 3, 4)
Name Description	Poly(A)-binding protein-dependent poly(A) riboNuclease 5

Chromosomal Location	ChrIX:369908 to 365466 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for PAN1
Molecular Function
Manually curated	protein binding, bridging (IPI)
Biological Process
Manually curated	actin cortical patch assembly (IMP) axial cellular bud site selection (IMP) bipolar cellular bud site selection (IMP) cytokinesis (IMP) endocytosis (IMP)
Cellular Component
Manually curated	actin cortical patch (IDA) cytoplasm (IDA) nucleus (IDA)
High-throughput	mating projection tip (IDA) plasma membrane (IDA)

Classical genetics
conditional	axial budding pattern: decreased rate bipolar budding pattern: decreased rate Clc1p distribution: abnormal
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable resistance to glycolaldehyde: decreased toxin resistance: increased
reduction of function	competitive fitness: decreased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	136 total interaction(s) for 60 unique genes/features.
Physical Interactions	Affinity Capture-MS: 20 Affinity Capture-RNA: 2 Affinity Capture-Western: 17 Biochemical Activity: 7 Reconstituted Complex: 9 Two-hybrid: 26
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 8 Phenotypic Enhancement: 5 Phenotypic Suppression: 4 Synthetic Growth Defect: 8 Synthetic Lethality: 24 Synthetic Rescue: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:369908 to 365466 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..4443 369908..365466 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001445