IST3/YIR005W Summary

IST3 BASIC INFORMATION

Standard Name	IST3 1
Systematic Name	YIR005W
Alias	SNU17
Feature Type	ORF, Verified
Description	Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing (2, 3, 4)
Name Description	Increased Sodium Tolerance 1

GO Annotations	All IST3 GO evidence and references
	View Computational GO annotations for IST3
Molecular Function
Manually curated	contributes_to first spliceosomal transesterification activity (IDA, IMP)
Biological Process
Manually curated	generation of catalytic spliceosome for first transesterification step (IMP) mRNA export from nucleus (IMP) nuclear mRNA splicing, via spliceosome (IDA, IPI) spliceosome assembly (IMP)
Cellular Component
Manually curated	RES complex (IDA) U2 snRNP (IDA)

Mutant Phenotype	All IST3 Phenotype details and references
Large-scale survey
null	acid pH resistance: decreased bud morphology: abnormal budding pattern: abnormal cell shape: abnormal chitin deposition: decreased competitive fitness: decreased fermentative growth: decreased rate haploinsufficient resistance to Calcofluor White: normal respiratory growth: decreased rate utilization of phosphorus source: decreased viable

Interactions	IST3 All interactions details and references
	180 total interaction(s) for 126 unique genes/features.
Physical Interactions	Affinity Capture-MS: 21 Co-purification: 1 Reconstituted Complex: 7 Two-hybrid: 5
Genetic Interactions	Phenotypic Enhancement: 79 Phenotypic Suppression: 44 Synthetic Growth Defect: 18 Synthetic Lethality: 5

Sequence Information

ChrIX:364886 to 365332 | |

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..447	364886..365332	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001444

IST3 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for IST3

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for IST3]

1)	Entian KD, et al. (1999) Functional analysis of 150 deletion mutants in Saccharomyces cerevisiae by a systematic approach. Mol Gen Genet 262(4-5):683-702
2)	Gottschalk A, et al. (2001) A novel yeast U2 snRNP protein, Snu17p, is required for the first catalytic step of splicing and for progression of spliceosome assembly. Mol Cell Biol 21(9):3037-46
3)	Wang Q and Rymond BC (2003) Rds3p is required for stable U2 snRNP recruitment to the splicing apparatus. Mol Cell Biol 23(20):7339-49
4)	Spingola M, et al. (2004) Mer1p is a modular splicing factor whose function depends on the conserved U2 snRNP protein Snu17p. Nucleic Acids Res 32(3):1242-50

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