AIM21/YIR003W Summary

AIM21 BASIC INFORMATION

Standard Name	AIM21 1
Systematic Name	YIR003W
Feature Type	ORF, Verified
Description	Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton (1, 2, 3, 4, 5, 6)
Name Description	Altered Inheritance rate of Mitochondria 1

GO Annotations	All AIM21 GO evidence and references
	View Computational GO annotations for AIM21
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	mitochondrial migration along actin filament (IMP)
Cellular Component
High-throughput	actin cytoskeleton (IDA) mating projection tip (IDA) colocalizes_with ribosome (IDA)

Mutant Phenotype	All AIM21 Phenotype details and references
Large-scale survey
null	mitochondrial genome maintenance: abnormal resistance to farnesol: decreased resistance to 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid: decreased toxin resistance: increased viable

Interactions	AIM21 All interactions details and references
	30 total interaction(s) for 16 unique genes/features.
Physical Interactions	Affinity Capture-MS: 11 Affinity Capture-RNA: 1 Affinity Capture-Western: 1 Biochemical Activity: 6 PCA: 2 Protein-peptide: 2 Two-hybrid: 3
Genetic Interactions	Synthetic Lethality: 4

Sequence Information

ChrIX:360882 to 362921 | |

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2040	360882..362921	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001442

AIM21 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for AIM21

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for AIM21]

1)	Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
2)	Fazi B, et al. (2002) Unusual binding properties of the SH3 domain of the yeast actin-binding protein Abp1: structural and functional analysis. J Biol Chem 277(7):5290-8
3)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
4)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5)	Landgraf C, et al. (2004) Protein interaction networks by proteome peptide scanning. PLoS Biol 2(1):E14
6)	Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307

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