HXT12/YIL170W Summary Help

Standard Name HXT12 1
Systematic Name YIL170W
Feature Type pseudogene
Description Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family (1, 2, 3, 4 and see Summary Paragraph)
Name Description HeXose Transporter 1
Chromosomal Location
ChrIX:19847 to 21220 | ORF Map | GBrowse
Gene Ontology Annotations All HXT12 GO evidence and references
  View Computational GO annotations for HXT12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Large-scale survey
6 total interaction(s) for 5 unique genes/features.
Physical Interactions
  • PCA: 1

Genetic Interactions
  • Negative Genetic: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 1

Expression Summary
Length (a.a.) 457
Molecular Weight (Da) 50,830
Isoelectric Point (pI) 8.48
Phosphorylation PhosphoGRID
sequence information
ChrIX:19847 to 21220 | ORF Map | GBrowse
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1374 19847..21220 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
External Links All Associated Seq | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000001432

HXT12 was identified through the systematic sequencing project as having high similarity to other representatives of the 18-20 member S. cerevisiae hexose transporter family (3, 4, 2, 5) HXT12 is represented in SGD as two separate ORFs, YIL170w and YIL171w, and may be a pseudogene; deletion of two nucleotides from the systematic sequence is required to yield the predicted Hxt12p sequence (3, 4) HXT12, linked to the telomere of chromosome IX-L, is most similar to subtelomeric genes HXT11 (chromosome XV-L; 98% amino acid identity) and HXT9 (chromosome X-L; 97% amino acid identity) (4). The high similarity of HXT12's sequence to other HXT genes suggests that either it is a recently formed pseudogene, or there is an error in the systematic sequence (3, 4, 2). When 18 members of the hexose transporter family were amplified from genomic DNA and overexpressed, HXT12 was the only one unable to transport hexoses, supporting its designation as a pseudogene (2). In common with all the HXT genes, deletions of YIL170w and YIL171w are viable (2).

Last updated: 2002-03-04 Contact SGD

References cited on this page View Complete Literature Guide for HXT12
1) Andre B  (1995) An overview of membrane transport proteins in Saccharomyces cerevisiae. Yeast 11(16):1575-611
2) Wieczorke R, et al.  (1999) Concurrent knock-out of at least 20 transporter genes is required to block uptake of hexoses in Saccharomyces cerevisiae. FEBS Lett 464(3):123-8
3) Nelissen B, et al.  (1995) Phylogenetic classification of the major superfamily of membrane transport facilitators, as deduced from yeast genome sequencing. FEBS Lett 377(2):232-6
4) Kruckeberg AL  (1996) The hexose transporter family of Saccharomyces cerevisiae. Arch Microbiol 166(5):283-92
5) Diderich JA, et al.  (1999) Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiae. J Biol Chem 274(22):15350-9