POT1/YIL160C Summary Help

Standard Name POT1 1
Systematic Name YIL160C
Alias FOX3 2 , POX3
Feature Type ORF, Verified
Description 3-ketoacyl-CoA thiolase with broad chain length specificity; cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids (3)
Name Description Peroxisomal Oxoacyl Thiolase 1
Chromosomal Location
ChrIX:41444 to 40191 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All POT1 GO evidence and references
  View Computational GO annotations for POT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Pathways
Classical genetics
null
Large-scale survey
null
Resources
84 total interaction(s) for 69 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-Western: 8
  • Co-crystal Structure: 2
  • Co-purification: 1
  • Reconstituted Complex: 3
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 55
  • Phenotypic Enhancement: 1
  • Positive Genetic: 8
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 417
Molecular Weight (Da) 44,730
Isoelectric Point (pI) 7.56
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:41444 to 40191 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1254 41444..40191 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001422
References cited on this page View Complete Literature Guide for POT1
1) Igual JC, et al.  (1991) A new glucose-repressible gene identified from the analysis of chromatin structure in deletion mutants of yeast SUC2 locus. Yeast 7(4):379-89
2) Erdmann R  (1994) The peroxisomal targeting signal of 3-oxoacyl-CoA thiolase from Saccharomyces cerevisiae. Yeast 10(7):935-44
3) Mathieu M, et al.  (1997) The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism. J Mol Biol 273(3):714-28