IMP2'/YIL154C Summary Help

Standard Name IMP2' 1
Systematic Name YIL154C
Alias IMP2 2
Feature Type ORF, Verified
Description Transcriptional activator involved in maintenance of ion homeostasis; also involved in protection against DNA damage caused by bleomycin and other oxidants; contains a C-terminal leucine-rich repeat (3, 4 and see Summary Paragraph)
Name Description Independent of Mitochondria1 Particle 2
Chromosomal Location
ChrIX:55021 to 53981 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All IMP2' GO evidence and references
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 1 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
unspecified
Resources
80 total interaction(s) for 74 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 13
  • Biochemical Activity: 1

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 4
  • Negative Genetic: 40
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 1
  • Positive Genetic: 1
  • Synthetic Growth Defect: 6
  • Synthetic Haploinsufficiency: 1
  • Synthetic Lethality: 4
  • Synthetic Rescue: 4

Resources
Expression Summary
histogram
Resources
Length (a.a.) 346
Molecular Weight (Da) 39,070
Isoelectric Point (pI) 4.78
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:55021 to 53981 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1041 55021..53981 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001416
SUMMARY PARAGRAPH for IMP2'

IMP2' was originally isolated as a mutant defective in maltose, galactose and raffinose metabolism (2). IMP2' is required for the rapid glucose derepression of the maltose, galactose, raffinose and ethanol utilization pathways, and it has been shown that Imp2'p regulates galactose- and maltose-inducible genes at the transcriptional level (5). In addition, molecular analysis of IMP2' indicates that it encodes a transcription factor that can activate a reporter gene (4). IMP2' was also isolated in a screen for bleomycin mutants; bleomycin is an antitumor drug that damages DNA by producing free radicals (4). imp2' mutants are sensitive to other DNA damaging agents, suggesting that Imp2p' is involved in regulation of genes involved in DNA repair (4).

Note: this gene is designated IMP2' in SGD because another gene has also been referred to as IMP2 in the literature. The other IMP2 gene (ORF YMR035W) is a mitochondrial protease that cleaves signal sequences from proteins targeted to the mitochondrial intermembrane space.

Last updated: 2000-06-09 Contact SGD

References cited on this page View Complete Literature Guide for IMP2'
1) Donnini, C.  (1992) Personal Communication, Mortimer Map Edition 11
2) Donnini C, et al.  (1992) IMP2, a nuclear gene controlling the mitochondrial dependence of galactose, maltose and raffinose utilization in Saccharomyces cerevisiae. Yeast 8(2):83-93
3) Masson JY and Ramotar D  (1998) The transcriptional activator Imp2p maintains ion homeostasis in Saccharomyces cerevisiae. Genetics 149(2):893-901
4) Masson JY and Ramotar D  (1996) The Saccharomyces cerevisiae IMP2 gene encodes a transcriptional activator that mediates protection against DNA damage caused by bleomycin and other oxidants. Mol Cell Biol 16(5):2091-100
5) Lodi T, et al.  (1995) IMP2, a gene involved in the expression of glucose-repressible genes in Saccharomyces cerevisiae. Microbiology 141 ( Pt 9)():2201-9