MLP2/YIL149C Summary

MLP2 BASIC INFORMATION

Standard Name	MLP2
Systematic Name	YIL149C
Feature Type	ORF, Verified
Description	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length (1, 2)
Name Description	Myosin-Like Protein 2

GO Annotations	All MLP2 GO evidence and references
	View Computational GO annotations for MLP2
Molecular Function
Manually curated	ribonucleoprotein binding (IGI, IPI)
Biological Process
Manually curated	mRNA export from nucleus (IGI, IPI) protein import into nucleus (IGI) regulation of transcription (IEP, IGI) spindle pole body organization (IMP)
Cellular Component
Manually curated	nuclear envelope (IDA) nucleoplasm (IDA) colocalizes_with ribonucleoprotein complex (IPI) colocalizes_with spindle pole body (IDA) spindle pole body (IPI)
High-throughput	mitochondrion (IDA)

Mutant Phenotype	All MLP2 Phenotype details and references
Classical genetics
null	cell cycle progression in M phase: abnormal cellular morphology: abnormal position of spindle pole body: abnormal Spc42p accumulation: increased spindle morphology: abnormal telomere length: increased
Large-scale survey
null	viable

Interactions	MLP2 All interactions details and references
	57 total interaction(s) for 41 unique genes/features.
Physical Interactions	Affinity Capture-MS: 19 Affinity Capture-Western: 10 Co-localization: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 11 Phenotypic Suppression: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 5 Synthetic Rescue: 4

Sequence Information

ChrIX:68067 to 63028 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..5040	68067..63028	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001411

MLP2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for MLP2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for MLP2]

1)	Strambio-de-Castillia C, et al. (1999) Proteins connecting the nuclear pore complex with the nuclear interior. J Cell Biol 144(5):839-55
2)	Hediger F, et al. (2002) Myosin-like proteins 1 and 2 are not required for silencing or telomere anchoring, but act in the Tel1 pathway of telomere length control. J Struct Biol 140(1-3):79-91

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