OM45/YIL136W Summary Help

Standard Name OM45 1
Systematic Name YIL136W
Feature Type ORF, Verified
Description Mitochondrial outer membrane protein of unknown function; major constituent of the outer membrane, located on the outer (cytosolic) face; protein abundance increases in response to DNA replication stress (1, 2, 3)
Name Description Outer Membrane 1
Chromosomal Location
ChrIX:93619 to 94800 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All OM45 GO evidence and references
  View Computational GO annotations for OM45
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
41 total interaction(s) for 37 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 3
  • Co-fractionation: 2
  • Co-localization: 3
  • Two-hybrid: 4

Genetic Interactions
  • Negative Genetic: 15
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 393
Molecular Weight (Da) 44,580
Isoelectric Point (pI) 9.38
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:93619 to 94800 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1182 93619..94800 1994-12-10 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001398
References cited on this page View Complete Literature Guide for OM45
1) Yaffe MP, et al.  (1989) The major 45-kDa protein of the yeast mitochondrial outer membrane is not essential for cell growth or mitochondrial function. J Biol Chem 264(35):21091-6
2) Cerveny KL, et al.  (2001) Division of mitochondria requires a novel DMN1-interacting protein, Net2p. Mol Biol Cell 12(2):309-21
3) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76