Standard Name	AYR1
Systematic Name	YIL124W
Feature Type	ORF, Verified
Description	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones (1, 2, 3)
Name Description	1-AcyldihYdroxyacetone-phosphate Reductase 1
Gene Product Alias	1-acyl dihydroxyacetone phosphate reductase 1

Chromosomal Location	ChrIX:126204 to 127097 | ORF Map | GBrowse

	View Computational GO annotations for AYR1
Molecular Function
Manually curated	acylglycerone-phosphate reductase activity (IMP)
Biological Process
Manually curated	phosphatidic acid biosynthetic process (IMP)
Cellular Component
Manually curated	endoplasmic reticulum (IDA) lipid particle (IDA)
High-throughput	cytoplasm (IDA) integral to membrane (ISM) mitochondrial outer membrane (IDA) mitochondrion (IDA)

Pathways	phosphatidate biosynthesis I (the dihydroxyacetone pathway) phosphatidic acid and phospholipid biosynthesis superpathway of phosphatidate biosynthesis

Classical genetics
null	Fus-Mid-GFP distribution: abnormal spore germination: absent viable
overexpression	vegetative growth: arrested
Large-scale survey
null	bud morphology: abnormal competitive fitness: increased haploinsufficient hyperosmotic stress resistance: decreased Fus-Mid-GFP distribution: abnormal resistance to mefloquine: decreased resistance to ethanol: decreased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: decreased rate viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	50 total interaction(s) for 43 unique genes/features.
Physical Interactions	Affinity Capture-MS: 7 Affinity Capture-RNA: 3 Co-fractionation: 1 PCA: 14 Two-hybrid: 1
Genetic Interactions	Negative Genetic: 14 Positive Genetic: 6 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:126204 to 127097 | ORF Map | GBrowse
Last Update	Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..894 126204..127097 1994-12-10 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001386