SIM1/YIL123W Summary Help

Standard Name SIM1 1
Systematic Name YIL123W
Feature Type ORF, Verified
Description Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p); may participate in DNA replication; promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated; SIM1 has a paralog, SUN4, that arose from the whole genome duplication (2, 3)
Name Description Start Independent of Mitosis 1
Chromosomal Location
ChrIX:128151 to 129581 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All SIM1 GO evidence and references
  View Computational GO annotations for SIM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 24 genes
Resources
Large-scale survey
null
Resources
41 total interaction(s) for 31 unique genes/features.
Physical Interactions
  • Affinity Capture-Luminescence: 1
  • Affinity Capture-MS: 2
  • Affinity Capture-RNA: 5
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 6
  • Negative Genetic: 17
  • Phenotypic Enhancement: 2
  • Phenotypic Suppression: 1
  • Positive Genetic: 3
  • Synthetic Growth Defect: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 476
Molecular Weight (Da) 48,190
Isoelectric Point (pI) 4.2
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:128151 to 129581 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 2011-02-03
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
5' UTR intron -489..-3 127662..128148 2007-04-04 2007-04-04
CDS 1..1431 128151..129581 2011-02-03 2011-02-03
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001385
References cited on this page View Complete Literature Guide for SIM1
1) Dahmann C, et al.  (1995) S-phase-promoting cyclin-dependent kinases prevent re-replication by inhibiting the transition of replication origins to a pre-replicative state. Curr Biol 5(11):1257-69
2) Mouassite M, et al.  (2000) The SUN family of Saccharomyces cerevisiae: the double knock-out of UTH1 and SIM1 promotes defects in nucleus migration and increased drug sensitivity. FEMS Microbiol Lett 182(1):137-41
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61