SUMMARY PARAGRAPH for RHO3
RHO3 encodes a non-essential small GTPase in the Rho/Rac subfamily of Ras-like GTPases (4). Other S. cerevisiae Rho GTPases are encoded by RHO1, RHO2, RHO4, RHO5, and CDC42 (2). Like other eukaryotic Rho-type GTPases, Rho3p is involved in the establishment of cell polarity (2). Temperature sensitive rho3 mutants lose cell polarity at the restrictive temperature; a dominant RHO3 allele causes cold sensitivity and aberrant cell morphology (5). RHO3 interacts genetically with SEC4, which encodes a Rab-type small GTPase, suggesting that Rho3p may regulate polarized secretion (5, 2). rho3 and rho4 null mutations are synthetically lethal (4, 2). The GTPase activity of Rho3p is positively regulated by the GTPase activating protein (GAP) Rgd1p (1).
Last updated: 1999-11-24