ICE2/YIL090W Summary Help

Standard Name ICE2 1
Systematic Name YIL090W
Feature Type ORF, Verified
Description Integral ER membrane protein with type-III transmembrane domains; required for maintenance of ER zinc homeostasis; necessary for efficient targeting of Trm1p tRNA methyltransferase to inner nuclear membrane; mutations cause defects in cortical ER morphology in both the mother and daughter cells (1, 2, 3)
Name Description Inheritance of Cortical ER 1
Chromosomal Location
ChrIX:193595 to 195070 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ICE2 GO evidence and references
  View Computational GO annotations for ICE2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
559 total interaction(s) for 303 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1
  • Affinity Capture-RNA: 1

Genetic Interactions
  • Negative Genetic: 338
  • Phenotypic Enhancement: 10
  • Phenotypic Suppression: 16
  • Positive Genetic: 174
  • Synthetic Growth Defect: 15
  • Synthetic Lethality: 3
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 491
Molecular Weight (Da) 56,332
Isoelectric Point (pI) 9.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:193595 to 195070 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1476 193595..195070 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001352
References cited on this page View Complete Literature Guide for ICE2
1) de Martin PE, et al.  (2005) Ice2p is important for the distribution and structure of the cortical ER network in Saccharomyces cerevisiae. J Cell Sci 118(Pt 1):65-77
2) Murthi A and Hopper AK  (2005) Genome-wide screen for inner nuclear membrane protein targeting in Saccharomyces cerevisiae: roles for N-acetylation and an integral membrane protein. Genetics 170(4):1553-60
3) North M, et al.  (2012) Genome-Wide Functional Profiling Identifies Genes and Processes Important for Zinc-Limited Growth of Saccharomyces cerevisiae. PLoS Genet 8(6):e1002699