SDS3/YIL084C Summary Help

Standard Name SDS3 1
Systematic Name YIL084C
Feature Type ORF, Verified
Description Component of the Rpd3L histone deacetylase complex; required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; relocalizes to the cytosol in response to hypoxia; cells defective in SDS3 display pleiotropic phenotypes (2, 3, 4, 5, 6)
Name Description Suppressor of Defective Silencing 7
Chromosomal Location
ChrIX:203259 to 202276 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SDS3 GO evidence and references
  View Computational GO annotations for SDS3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 2 genes
Classical genetics
Large-scale survey
571 total interaction(s) for 323 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 54
  • Affinity Capture-Western: 10
  • Biochemical Activity: 3
  • Co-purification: 1
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 4
  • Negative Genetic: 346
  • Phenotypic Enhancement: 1
  • Phenotypic Suppression: 12
  • Positive Genetic: 74
  • Synthetic Growth Defect: 35
  • Synthetic Lethality: 14
  • Synthetic Rescue: 13

Expression Summary
Length (a.a.) 327
Molecular Weight (Da) 37,625
Isoelectric Point (pI) 9.61
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIX:203259 to 202276 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..984 203259..202276 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001346
References cited on this page View Complete Literature Guide for SDS3
1) Sussel L, et al.  (1995) Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics 141(3):873-88
2) Vannier D, et al.  (1996) Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. Genetics 144(4):1343-53
3) Vannier D, et al.  (2001) A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae. Mol Genet Genomics 265(3):560-8
4) Lechner T, et al.  (2000) Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity. J Biol Chem 275(52):40961-6
5) Carrozza MJ, et al.  (2005) Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex. Biochim Biophys Acta 1731(2):77-87; discussion 75-6
6) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
7) Sussel L, et al.  (1993) Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae. Mol Cell Biol 13(7):3919-28