RPN2/YIL075C Summary

RPN2 BASIC INFORMATION

Standard Name	RPN2 1
Systematic Name	YIL075C
Alias	SEN3 2
Feature Type	ORF, Verified
Description	Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p (2, 3)
Name Description	Regulatory Particle Non-ATPase 1

GO Annotations	All RPN2 GO evidence and references
	View Computational GO annotations for RPN2
Molecular Function
Manually curated	contributes_to endopeptidase activity (IMP) protein binding, bridging (IPI)
Biological Process
Manually curated	proteasome assembly (IGI) ubiquitin-dependent protein catabolic process (IMP, IPI)
Cellular Component
Manually curated	nucleus (IDA) proteasome regulatory particle, base subcomplex (IPI) proteasome storage granule (IDA)

Mutant Phenotype	All RPN2 Phenotype details and references
Classical genetics
conditional	toxin resistance: decreased
Large-scale survey
null	filamentous growth: increased inviable

Interactions	RPN2 All interactions details and references
	164 total interaction(s) for 73 unique genes/features.
Physical Interactions	Affinity Capture-MS: 95 Affinity Capture-Western: 9 Biochemical Activity: 5 Co-fractionation: 1 Co-purification: 4 PCA: 1 Reconstituted Complex: 8 Two-hybrid: 1
Genetic Interactions	Dosage Rescue: 1 Phenotypic Enhancement: 7 Phenotypic Suppression: 1 Synthetic Growth Defect: 26 Synthetic Lethality: 4 Synthetic Rescue: 1

Sequence Information

ChrIX:220697 to 217860 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2838	220697..217860	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001337

RPN2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for RPN2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RPN2]

1)	Finley D, et al. (1998) Unified nomenclature for subunits of the Saccharomyces cerevisiae proteasome regulatory particle. Trends Biochem Sci 23(7):244-5
2)	DeMarini DJ, et al. (1995) The yeast SEN3 gene encodes a regulatory subunit of the 26S proteasome complex required for ubiquitin-dependent protein degradation in vivo. Mol Cell Biol 15(11):6311-21
3)	Kimura Y, et al. (2003) N-Terminal modifications of the 19S regulatory particle subunits of the yeast proteasome. Arch Biochem Biophys 409(2):341-8

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