Standard Name	RPN2 1
Systematic Name	YIL075C
Alias	SEN3 2
Feature Type	ORF, Verified
Description	Subunit of the 26S proteasome; substrate of the N-acetyltransferase Nat1p; protein abundance increases in response to DNA replication stress (2, 3, 4)
Name Description	Regulatory Particle Non-ATPase 1

Chromosomal Location	ChrIX:220700 to 217863 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for RPN2
Molecular Function
Manually curated	contributes_to endopeptidase activity (IMP) protein binding, bridging (IPI)
Biological Process
Manually curated	proteasome assembly (IGI) ubiquitin-dependent protein catabolic process (IMP, IPI)
Cellular Component
Manually curated	nucleus (IDA) proteasome regulatory particle, base subcomplex (IDA) proteasome storage granule (IDA)
High-throughput	nucleus (IDA)

Classical genetics
conditional	toxin resistance: decreased
Large-scale survey
null	filamentous growth: increased haploinsufficient inviable resistance to clioquinol: decreased
reduction of function	competitive fitness: increased resistance to methyl methanesulfonate: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	230 total interaction(s) for 91 unique genes/features.
Physical Interactions	Affinity Capture-MS: 140 Affinity Capture-RNA: 3 Affinity Capture-Western: 16 Biochemical Activity: 5 Co-crystal Structure: 2 Co-fractionation: 1 Co-purification: 6 PCA: 1 Reconstituted Complex: 11 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 1 Negative Genetic: 17 Phenotypic Enhancement: 2 Positive Genetic: 13 Synthetic Growth Defect: 4 Synthetic Lethality: 5 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:220700 to 217863 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2838 220700..217863 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001337