HOP1/YIL072W Summary Help

HOP1 BASIC INFORMATION

Standard Name HOP1
Systematic Name YIL072W
Feature Type ORF, Verified
Description Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation (1, 2, 3, 4 and see Summary Paragraph)
Name Description HOmolog Pairing 4
GO Annotations All HOP1 GO evidence and references
    View Computational GO annotations for HOP1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Mutant Phenotype All HOP1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions HOP1 All interactions details and references
30 total interaction(s) for 18 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 4
  • Biochemical Activity: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 3
Genetic Interactions
  • Dosage Rescue: 6
  • Phenotypic Enhancement: 3
  • Phenotypic Suppression: 10
  • Synthetic Rescue: 1
Sequence Information
ChrIX:226599 to 228416 | ORF Map | GBrowse
Gbrowse
Genetic position: -59 cM
Last Update Coordinates: 1994-12-10 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..1818 226599..228416 1994-12-10 1994-12-10
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001334

HOP1 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Localization Resources
  • Interactions
  • Phenotype Resources
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  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for HOP1

SUMMARY PARAGRAPH for HOP1

Red1p, Hop1p, and Mek1p are components of the axial element protein cores in synaptonemal complexes (5). Synaptonemal complexes are found at synapses between homologous chromosomes during meiosis, and form when sister chromatids condense upon axial elements (5). Maintenance of appropriate stoichiometry between Red1p, Hop1p, and Mek1p is important for effective chromosome segregation and for the meiotic recombination checkpoint (6). Red1p, Hop1p and Mek1p are also necessary for normal levels of double-strand break (DSB) formation (7), and are required to ensure that crossovers occur between homologous chromosomes and not between sister chromatids (6). Red1p is a multifunctional protein required for maximum activity of Mek1p, interaction between Mek1p and Hop1p, sister chromatid cohesion, establishment of interhomolog bias at double Holliday junctions, and for proper timing of the first meiotic division (6, 8, 9, 10).

Last updated: 2005-10-14

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HOP1]

1) Smith AV and Roeder GS  (1997) The yeast Red1 protein localizes to the cores of meiotic chromosomes. J Cell Biol 136(5):957-67
2) Vershon AK, et al.  (1992) Meiotic induction of the yeast HOP1 gene is controlled by positive and negative regulatory sites. Mol Cell Biol 12(9):3706-14
3) Hollingsworth NM, et al.  (1990) The HOP1 gene encodes a meiosis-specific component of yeast chromosomes. Cell 61(1):73-84
4) Hollingsworth NM and Byers B  (1989) HOP1: a yeast meiotic pairing gene. Genetics 121(3):445-62
5) de los Santos T, et al.  (2001) A role for MMS4 in the processing of recombination intermediates during meiosis in Saccharomyces cerevisiae. Genetics 159(4):1511-25
6) Wan L, et al.  (2004) Mek1 kinase activity functions downstream of RED1 in the regulation of meiotic double strand break repair in budding yeast. Mol Biol Cell 15(1):11-23
7) Prieler S, et al.  (2005) The control of Spo11's interaction with meiotic recombination hotspots. Genes Dev 19(2):255-69
8) Malone RE, et al.  (2004) The signal from the initiation of meiotic recombination to the first division of meiosis. Eukaryot Cell 3(3):598-609
9) Woltering D, et al.  (2000) Meiotic segregation, synapsis, and recombination checkpoint functions require physical interaction between the chromosomal proteins Red1p and Hop1p. Mol Cell Biol 20(18):6646-58
10) Zierhut C, et al.  (2004) Mnd1 is required for meiotic interhomolog repair. Curr Biol 14(9):752-62