SEC6/YIL068C Summary Help

Standard Name SEC6 1
Systematic Name YIL068C
Feature Type ORF, Verified
Description Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p (2, 3, 4, 5, 6)
Name Description SECretory
Chromosomal Location
ChrIX:235474 to 233057 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gene Ontology Annotations All SEC6 GO evidence and references
  View Computational GO annotations for SEC6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
reduction of function
146 total interaction(s) for 55 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 28
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 27
  • Co-fractionation: 5
  • Co-purification: 4
  • PCA: 6
  • Reconstituted Complex: 5
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Lethality: 2
  • Dosage Rescue: 6
  • Negative Genetic: 5
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 13
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 30
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 805
Molecular Weight (Da) 93,427
Isoelectric Point (pI) 4.87
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIX:235474 to 233057 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2418 235474..233057 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001330
References cited on this page View Complete Literature Guide for SEC6
1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) TerBush DR, et al.  (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
3) TerBush DR and Novick P  (1995) Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol 130(2):299-312
4) Sivaram MV, et al.  (2005) Dimerization of the exocyst protein Sec6p and its interaction with the t-SNARE Sec9p. Biochemistry 44(16):6302-11
5) Songer JA and Munson M  (2009) Sec6p anchors the assembled exocyst complex at sites of secretion. Mol Biol Cell 20(3):973-82
6) Morgera F, et al.  (2012) Regulation of exocytosis by the exocyst subunit Sec6 and the SM protein Sec1. Mol Biol Cell 23(2):337-46