SEC6/YIL068C Summary

SEC6 BASIC INFORMATION

Standard Name	SEC6 1
Systematic Name	YIL068C
Feature Type	ORF, Verified
Description	Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly (2, 3, 4)
Name Description	SECretory

GO Annotations	All SEC6 GO evidence and references
	View Computational GO annotations for SEC6
Molecular Function
Manually curated	protein binding (IPI)
Biological Process
Manually curated	bipolar cellular bud site selection (TAS) cytokinesis (TAS) Golgi to plasma membrane transport (TAS) vesicle docking during exocytosis (TAS) vesicle fusion (TAS)
Cellular Component
Manually curated	cellular bud tip (IPI) exocyst (IPI)
High-throughput	mating projection tip (IDA)

Mutant Phenotype	All SEC6 Phenotype details and references
Classical genetics
conditional	endomembrane system morphology: abnormal invertase secretion: decreased invertase accumulation: increased FusMidp distribution: abnormal
Large-scale survey
null	inviable

Interactions	SEC6 All interactions details and references
	115 total interaction(s) for 39 unique genes/features.
Physical Interactions	Affinity Capture-MS: 26 Affinity Capture-RNA: 1 Affinity Capture-Western: 20 Co-fractionation: 4 Co-purification: 2 PCA: 6 Reconstituted Complex: 3 Two-hybrid: 1
Genetic Interactions	Dosage Growth Defect: 1 Dosage Lethality: 2 Dosage Rescue: 5 Phenotypic Enhancement: 7 Phenotypic Suppression: 4 Synthetic Growth Defect: 2 Synthetic Lethality: 30 Synthetic Rescue: 1

Sequence Information

ChrIX:235471 to 233054 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2418	235471..233054	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001330

SEC6 RESOURCES

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SGD ORF map	GBrowse

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Expression Summary

ADDITIONAL INFORMATION for SEC6

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SEC6]

1)	Novick P, et al. (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2)	TerBush DR, et al. (1996) The Exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15(23):6483-94
3)	TerBush DR and Novick P (1995) Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol 130(2):299-312
4)	Sivaram MV, et al. (2005) Dimerization of the exocyst protein Sec6p and its interaction with the t-SNARE Sec9p. Biochemistry 44(16):6302-11

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