Standard Name	FIS1 1
Systematic Name	YIL065C
Alias	MDV2 2
Feature Type	ORF, Verified
Description	Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation (1, 3, 4)
Name Description	mitochondrial FISsion 1

Chromosomal Location	ChrIX:241775 to 241308 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for FIS1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	chronological cell aging (IMP) mitochondrial fission (IGI, IMP) peroxisome fission (IGI) peroxisome organization (IMP)
Cellular Component
Manually curated	mitochondrial outer membrane (IDA) peroxisome (IDA)
High-throughput	mitochondrial outer membrane (IDA) mitochondrion (IDA)

Classical genetics
null	apoptosis: increased tellurium atom accumulation: increased peroxisomal morphology: abnormal resistance to hydrogen peroxide: decreased resistance to BAR0329: decreased resistance to tellurite: decreased survival rate in stationary phase: increased viability: decreased
overexpression	cell cycle progression in G1 phase: abnormal
reduction of function	mitochondrial morphology: abnormal
Large-scale survey
null	acid pH resistance: decreased proton accumulation: increased glycogen accumulation: decreased proton accumulation: decreased glutathione excretion: increased competitive fitness: decreased dessication resistance: decreased filamentous growth: decreased hyperosmotic stress resistance: decreased invasive growth: absent mitochondrial morphology: abnormal mitophagy: absent resistance to streptomycin: decreased resistance to paromomycin: decreased resistance to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO): decreased resistance to tunicamycin: decreased resistance to 1,4-dithiothreitol: decreased resistance to BPS: decreased resistance to cycloheximide: decreased resistance to benzo[a]pyrene: decreased stress resistance: increased toxin resistance: decreased vacuolar morphology: abnormal vegetative growth: abnormal vegetative growth: decreased rate
overexpression	vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	154 total interaction(s) for 102 unique genes/features.
Physical Interactions	Affinity Capture-MS: 4 Affinity Capture-RNA: 1 Affinity Capture-Western: 10 Co-crystal Structure: 3 Co-localization: 4 PCA: 3 Reconstituted Complex: 5 Two-hybrid: 17
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 79 Phenotypic Enhancement: 9 Phenotypic Suppression: 2 Positive Genetic: 9 Synthetic Growth Defect: 2 Synthetic Lethality: 1 Synthetic Rescue: 3
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:241775 to 241308 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..468 241775..241308 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001327