YRB2/YIL063C Summary

YRB2 BASIC INFORMATION

Standard Name	YRB2 1, 2
Systematic Name	YIL063C
Feature Type	ORF, Verified
Description	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential (1, 2, 3, 4)
Name Description	Yeast Ran Binder 1, 2

GO Annotations	All YRB2 GO evidence and references
	View Computational GO annotations for YRB2
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	protein export from nucleus (IMP) regulation of chromatin silencing at telomere (IMP) ribosomal small subunit export from nucleus (IMP)
Cellular Component
Manually curated	nuclear pore (IDA) nucleus (IDA)

Mutant Phenotype	All YRB2 Phenotype details and references
Classical genetics
null	cold sensitivity: increased heat sensitivity: normal nuclear export: absent viable
Large-scale survey
null	inviable

Interactions	YRB2 All interactions details and references
	49 total interaction(s) for 34 unique genes/features.
Physical Interactions	Affinity Capture-MS: 18 Affinity Capture-RNA: 1 Affinity Capture-Western: 5 Biochemical Activity: 1 Co-purification: 1 Reconstituted Complex: 2 Two-hybrid: 4
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 2 Phenotypic Enhancement: 7 Synthetic Lethality: 6 Synthetic Rescue: 1

Sequence Information

ChrIX:243741 to 242758 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 1994-12-10 | Sequence: 1994-12-10

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..984	243741..242758	1994-12-10	1994-12-10

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001325

YRB2 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for YRB2

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for YRB2]

1)	Taura T, et al. (1997) Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue. J Biol Chem 272(50):31877-84
2)	Noguchi E, et al. (1997) Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein. Mol Cell Biol 17(4):2235-46
3)	Taura T, et al. (1998) A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export. Proc Natl Acad Sci U S A 95(13):7427-32
4)	Maurer P, et al. (2001) The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p). Mol Biol Cell 12(3):539-49

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