APQ12/YIL040W Summary Help

Standard Name APQ12 1
Systematic Name YIL040W
Feature Type ORF, Verified
Description Protein required for nuclear envelope morphology; nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism (1, 2, 3)
Name Description APical growth revealed by Quantitative morphological analysis
Chromosomal Location
ChrIX:277723 to 278139 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All APQ12 GO evidence and references
  View Computational GO annotations for APQ12
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
612 total interaction(s) for 409 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 391
  • Phenotypic Suppression: 1
  • Positive Genetic: 152
  • Synthetic Growth Defect: 37
  • Synthetic Lethality: 19
  • Synthetic Rescue: 9

Resources
Expression Summary
histogram
Resources
Length (a.a.) 138
Molecular Weight (Da) 16,508
Isoelectric Point (pI) 9.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:277723 to 278139 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..417 277723..278139 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001302
References cited on this page View Complete Literature Guide for APQ12
1) Baker KE, et al.  (2004) The yeast Apq12 protein affects nucleocytoplasmic mRNA transport. RNA 10(9):1352-8
2) Scarcelli JJ, et al.  (2007) The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes. J Cell Biol 178(5):799-812
3) Hodg CA, et al.  (2010) Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum. J Cell Sci 123(Pt 1):141-151