Standard Name	NOT3
Systematic Name	YIL038C
Feature Type	ORF, Verified
Description	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation (1, 2)

Chromosomal Location	ChrIX:282652 to 280142 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for NOT3
Molecular Function
Manually curated	contributes_to ubiquitin-protein ligase activity (IMP)
Biological Process
Manually curated	nuclear-transcribed mRNA poly(A) tail shortening (IDA) positive regulation of transcription elongation from RNA polymerase II promoter (IDA, IPI) protein ubiquitination (IMP) regulation of transcription from RNA polymerase II promoter (IPI)
Cellular Component
Manually curated	CCR4-NOT core complex (IPI) cytoplasm (IDA)

Regulatory modules	predicted: stressResponse (505, 475, 415, 409, 397) predicted: cellcycle (329) predicted: stressResponse (505, 475, 415, 409, 397) predicted: cellcycle (329)

Classical genetics
null	prion formation: increased resistance to hydroxyurea: decreased resistance to sirolimus: decreased resistance to zymocin: decreased viable
Large-scale survey
null	competitive fitness: decreased heat sensitivity: increased Can1p-GFP distribution: abnormal resistance to 1,4-dithiothreitol: decreased resistance to cisplatin: increased resistance to tunicamycin: decreased resistance to fenpropimorph: decreased resistance to caffeine: decreased resistance to hydroxyurea: increased resistance to camptothecin: increased resistance to bleomycin: increased sporulation efficiency: increased starvation resistance: decreased stress resistance: decreased toxin resistance: increased vacuolar morphology: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	163 total interaction(s) for 115 unique genes/features.
Physical Interactions	Affinity Capture-MS: 17 Affinity Capture-Western: 16 Biochemical Activity: 3 Co-purification: 1 PCA: 12 Two-hybrid: 56
Genetic Interactions	Dosage Growth Defect: 1 Dosage Rescue: 3 Negative Genetic: 21 Phenotypic Enhancement: 2 Phenotypic Suppression: 4 Positive Genetic: 12 Synthetic Growth Defect: 5 Synthetic Haploinsufficiency: 1 Synthetic Lethality: 4 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:282652 to 280142 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..2511 282652..280142 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001300