CST6/YIL036W Summary Help

Standard Name CST6 1
Systematic Name YIL036W
Alias ACA2 2 , SHF1 3
Feature Type ORF, Verified
Description Basic leucine zipper (bZIP) transcription factor, in ATF/CREB family; mediates transcriptional activation of NCE103 (encoding carbonic anhydrase) in response to low CO2 levels such as in the ambient air; proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability; relocalizes to the cytosol in response to hypoxia; CST6 has a paralog, ACA1, that arose from the whole genome duplication (1, 2, 4, 5, 6, 7)
Name Description Chromosome STability 1
Chromosomal Location
ChrIX:285666 to 287429 | ORF Map | GBrowse
Gene Ontology Annotations All CST6 GO evidence and references
  View Computational GO annotations for CST6
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 601 genes
Regulators 5 genes
Classical genetics
Large-scale survey
62 total interaction(s) for 57 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 1
  • PCA: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Dosage Rescue: 1
  • Negative Genetic: 21
  • Phenotypic Suppression: 1
  • Positive Genetic: 12
  • Synthetic Growth Defect: 4
  • Synthetic Rescue: 1

Expression Summary
Length (a.a.) 587
Molecular Weight (Da) 65,264
Isoelectric Point (pI) 8.19
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrIX:285666 to 287429 | ORF Map | GBrowse
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..1764 285666..287429 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001298
References cited on this page View Complete Literature Guide for CST6
1) Ouspenski II, et al.  (1999) New yeast genes important for chromosome integrity and segregation identified by dosage effects on genome stability. Nucleic Acids Res 27(15):3001-8
2) Garcia-Gimeno MA and Struhl K  (2000) Aca1 and Aca2, ATF/CREB activators in Saccharomyces cerevisiae, are important for carbon source utilization but not the response to stress. Mol Cell Biol 20(12):4340-9
3) Velmurugan S, et al.  (1998) The 2 micrometer plasmid stability system: analyses of the interactions among plasmid- and host-encoded components. Mol Cell Biol 18(12):7466-77
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Saleem RA, et al.  (2010) Integrated phosphoproteomics analysis of a signaling network governing nutrient response and peroxisome induction. Mol Cell Proteomics 9(9):2076-88
6) Cottier F, et al.  (2012) The bZIP Transcription Factor Rca1p Is a Central Regulator of a Novel CO(2) Sensing Pathway in Yeast. PLoS Pathog 8(1):e1002485
7) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
8) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87