ULP2/YIL031W Summary Help

Standard Name ULP2 1
Systematic Name YIL031W
Alias SMT4 2
Feature Type ORF, Verified
Description Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate (1, 3, 4)
Name Description UbL-specific Protease 1
Chromosomal Location
ChrIX:292633 to 295737 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All ULP2 GO evidence and references
  View Computational GO annotations for ULP2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
conditional
null
Large-scale survey
null
overexpression
reduction of function
Resources
310 total interaction(s) for 268 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 151
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 3
  • PCA: 91
  • Two-hybrid: 2

Genetic Interactions
  • Dosage Growth Defect: 3
  • Dosage Lethality: 1
  • Dosage Rescue: 12
  • Phenotypic Enhancement: 4
  • Phenotypic Suppression: 8
  • Synthetic Growth Defect: 5
  • Synthetic Lethality: 7
  • Synthetic Rescue: 20

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,034
Molecular Weight (Da) 116,881
Isoelectric Point (pI) 6.82
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:292633 to 295737 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3105 292633..295737 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001293
References cited on this page View Complete Literature Guide for ULP2
1) Li SJ and Hochstrasser M  (2000) The yeast ULP2 (SMT4) gene encodes a novel protease specific for the ubiquitin-like Smt3 protein. Mol Cell Biol 20(7):2367-77
2) Schwienhorst I, et al.  (2000) SUMO conjugation and deconjugation. Mol Gen Genet 263(5):771-86
3) Bachant J, et al.  (2002) The SUMO-1 isopeptidase Smt4 is linked to centromeric cohesion through SUMO-1 modification of DNA topoisomerase II. Mol Cell 9(6):1169-82
4) Ubersax JA, et al.  (2003) Targets of the cyclin-dependent kinase Cdk1. Nature 425(6960):859-64