Standard Name	ULP2
Systematic Name	YIL031W
Alias	SMT4
Feature Type	ORF, Verified
Description	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate (1, 2, 3)
Name Description	Ubiquitin-Like Protein

Chromosomal Location	ChrIX:292633 to 295737 | ORF Map | GBrowse

	View Computational GO annotations for ULP2
Molecular Function
Manually curated	cysteine-type peptidase activity (IDA, ISS) SUMO-specific protease activity (IDA, IMP)
Biological Process
Manually curated	chromosome condensation (IMP) mitotic spindle assembly checkpoint (IGI, IMP) plasmid maintenance (IMP) protein desumoylation (IDA, IMP)
Cellular Component
Manually curated	nucleus (IDA)

Classical genetics
conditional	resistance to doxorubicin: increased
null	cellular morphology: abnormal chromosome/plasmid maintenance: decreased heat sensitivity: increased resistance to benomyl: decreased resistance to hydroxyurea: decreased sporulation: abnormal
Large-scale survey
null	inviable
overexpression	vegetative growth: decreased rate
reduction of function	competitive fitness: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	157 total interaction(s) for 130 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 2 Biochemical Activity: 3 PCA: 91 Two-hybrid: 2
Genetic Interactions	Dosage Growth Defect: 3 Dosage Lethality: 1 Dosage Rescue: 12 Phenotypic Enhancement: 4 Phenotypic Suppression: 7 Synthetic Growth Defect: 5 Synthetic Lethality: 7 Synthetic Rescue: 20
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrIX:292633 to 295737 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3105 292633..295737 2011-02-03 1994-12-10
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain M22 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001293