URM1/YIL008W Summary Help

Standard Name URM1 1
Systematic Name YIL008W
Feature Type ORF, Verified
Description Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response (1, 2, 3, 4)
Name Description Ubiquitin Related Modifier 1
Chromosomal Location
ChrIX:342536 to 342835 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All URM1 GO evidence and references
  View Computational GO annotations for URM1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 6 genes
Resources
Classical genetics
null
reduction of function
Large-scale survey
null
Resources
199 total interaction(s) for 123 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 6
  • Affinity Capture-RNA: 4
  • Affinity Capture-Western: 1
  • Biochemical Activity: 2
  • Co-crystal Structure: 1
  • PCA: 2
  • Two-hybrid: 8

Genetic Interactions
  • Negative Genetic: 101
  • Phenotypic Enhancement: 4
  • Positive Genetic: 11
  • Synthetic Growth Defect: 48
  • Synthetic Lethality: 9
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 99
Molecular Weight (Da) 11,028
Isoelectric Point (pI) 4.14
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrIX:342536 to 342835 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1994-12-10
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..300 342536..342835 2011-02-03 1994-12-10
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001270
References cited on this page View Complete Literature Guide for URM1
1) Furukawa K, et al.  (2000) A protein conjugation system in yeast with homology to biosynthetic enzyme reaction of prokaryotes. J Biol Chem 275(11):7462-5
2) Goehring AS, et al.  (2003) Urmylation: a ubiquitin-like pathway that functions during invasive growth and budding in yeast. Mol Biol Cell 14(11):4329-41
3) Noma A, et al.  (2009) Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions. Nucleic Acids Res 37(4):1335-52
4) Leidel S, et al.  (2009) Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. Nature 458(7235):228-32