CRG1/YHR209W Summary Help

Standard Name CRG1 1
Systematic Name YHR209W
Feature Type ORF, Verified
Description S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin (1, 2, 3, 4)
Name Description Cantharidin Resistance Gene 1
Chromosomal Location
ChrVIII:519437 to 520312 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All CRG1 GO evidence and references
  View Computational GO annotations for CRG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 5 genes
Resources
Classical genetics
null
overexpression
unspecified
Large-scale survey
null
Resources
90 total interaction(s) for 79 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 1
  • Two-hybrid: 1

Genetic Interactions
  • Negative Genetic: 5
  • Synthetic Growth Defect: 68
  • Synthetic Lethality: 9
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 291
Molecular Weight (Da) 33,785
Isoelectric Point (pI) 5.85
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:519437 to 520312 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..876 519437..520312 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001252
References cited on this page View Complete Literature Guide for CRG1
1) Hoon S, et al.  (2008) An integrated platform of genomic assays reveals small-molecule bioactivities. Nat Chem Biol 4(8):498-506
2) Niewmierzycka A and Clarke S  (1999) S-Adenosylmethionine-dependent methylation in Saccharomyces cerevisiae. Identification of a novel protein arginine methyltransferase. J Biol Chem 274(2):814-24
3) Tsvetanova NG, et al.  (2010) Proteome-Wide Search Reveals Unexpected RNA-Binding Proteins in Saccharomyces cerevisiae.LID - e12671 [pii] PLoS One 5(9)
4) Lissina E, et al.  (2011) A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis. PLoS Genet 7(10):e1002332