SCH9/YHR205W Summary Help

Standard Name SCH9 1
Systematic Name YHR205W
Alias KOM1 , HRM2 2
Feature Type ORF, Verified
Description AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan (2, 3, 4, 5, 6, 7, 8, 9)
Chromosomal Location
ChrVIII:509363 to 511837 | ORF Map | GBrowse
Gene Ontology Annotations All SCH9 GO evidence and references
  View Computational GO annotations for SCH9
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 1 genes
Classical genetics
Large-scale survey
224 total interaction(s) for 151 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 7
  • Biochemical Activity: 21
  • Reconstituted Complex: 18

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 11
  • Negative Genetic: 59
  • Phenotypic Enhancement: 16
  • Phenotypic Suppression: 28
  • Positive Genetic: 11
  • Synthetic Growth Defect: 14
  • Synthetic Lethality: 8
  • Synthetic Rescue: 23

Expression Summary
Length (a.a.) 824
Molecular Weight (Da) 91,811
Isoelectric Point (pI) 6.04
Phosphorylation PhosphoGRID | PhosphoPep Database
sequence information
ChrVIII:509363 to 511837 | ORF Map | GBrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Most Recent Updates
Coordinates Sequence
CDS 1..2475 509363..511837 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001248
References cited on this page View Complete Literature Guide for SCH9
1) Toda T, et al.  (1988) SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev 2(5):517-27
2) Prusty R and Keil RL  (2004) SCH9, a putative protein kinase from Saccharomyces cerevisiae, affects HOT1-stimulated recombination. Mol Genet Genomics 272(3):264-74
3) Crauwels M, et al.  (1997) The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology 143 ( Pt 8)():2627-37
4) di Blasi F, et al.  (1993) The SCH9 protein kinase mRNA contains a long 5' leader with a small open reading frame. Yeast 9(1):21-32
5) Morano KA and Thiele DJ  (1999) The Sch9 protein kinase regulates Hsp90 chaperone complex signal transduction activity in vivo. EMBO J 18(21):5953-62
6) Fabrizio P, et al.  (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292(5515):288-90
7) Urban J, et al.  (2007) Sch9 is a major target of TORC1 in Saccharomyces cerevisiae. Mol Cell 26(5):663-74
8) Pascual-Ahuir A and Proft M  (2007) The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes. EMBO J 26(13):3098-108
9) Huang X, et al.  (2012) Down-regulating sphingolipid synthesis increases yeast lifespan. PLoS Genet 8(2):e1002493