Standard Name	EGD2 1
Systematic Name	YHR193C
Feature Type	ORF, Verified
Description	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes (1, 2, 3)
Name Description	Enhancer of Gal4 DNA binding 1

Chromosomal Location	ChrVIII:488236 to 487712 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for EGD2
Molecular Function
Manually curated	phosphatidic acid binding (IDA) phosphatidylinositol-3,5-bisphosphate binding (IDA) phosphatidylinositol-3-phosphate binding (IDA) phosphatidylinositol-4-phosphate binding (IDA) unfolded protein binding (IMP)
Biological Process
Manually curated	'de novo' cotranslational protein folding (IPI)
Cellular Component
Manually curated	nascent polypeptide-associated complex (IDA)

Classical genetics
null	mitochondrial genome maintenance: abnormal mitochondrial transport: abnormal resistance to adriamycin: decreased respiratory growth: decreased rate
Large-scale survey
null	haploproficient metal resistance: increased resistance to methyl methanesulfonate: decreased starvation resistance: decreased stress resistance: increased viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	91 total interaction(s) for 75 unique genes/features.
Physical Interactions	Affinity Capture-MS: 27 Affinity Capture-RNA: 4 Affinity Capture-Western: 12 Biochemical Activity: 1 Co-fractionation: 2 Co-purification: 1 PCA: 4 Two-hybrid: 6
Genetic Interactions	Negative Genetic: 23 Phenotypic Enhancement: 1 Phenotypic Suppression: 1 Positive Genetic: 4 Synthetic Growth Defect: 4 Synthetic Lethality: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:488236 to 487712 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..525 488236..487712 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB382 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001236