PTH1/YHR189W Summary Help

Standard Name PTH1
Systematic Name YHR189W
Feature Type ORF, Verified
Description One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2 (1, 2, 3, 4, 5)
Also known as: PTH
Name Description Peptidyl-Trna Hydrolase
Chromosomal Location
ChrVIII:484028 to 484600 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All PTH1 GO evidence and references
  View Computational GO annotations for PTH1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 5 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
193 total interaction(s) for 140 unique genes/features.
Physical Interactions
  • Reconstituted Complex: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 166
  • Positive Genetic: 21
  • Synthetic Growth Defect: 3
  • Synthetic Lethality: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 190
Molecular Weight (Da) 21,036
Isoelectric Point (pI) 10.73
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:484028 to 484600 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..573 484028..484600 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001232
References cited on this page View Complete Literature Guide for PTH1
1) Menez J, et al.  (2002) Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable. Mol Microbiol 45(1):123-9
2) Rosas-Sandoval G, et al.  (2002) Orthologs of a novel archaeal and of the bacterial peptidyl-tRNA hydrolase are nonessential in yeast. Proc Natl Acad Sci U S A 99(26):16707-12
3) Fromant M, et al.  (2003) Peptidyl-tRNA hydrolase from Sulfolobus solfataricus. Nucleic Acids Res 31(12):3227-35
4) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12