Standard Name	OYE2
Systematic Name	YHR179W
Feature Type	ORF, Verified
Description	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN); responsible for geraniol reduction into citronellol during fermentation; homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6, 7)
Name Description	Old Yellow Enzyme 1
Gene Product Alias	Old Yellow Enzyme

Chromosomal Location	ChrVIII:462502 to 463704 | ORF Map | GBrowse

	View Computational GO annotations for OYE2
Molecular Function
Manually curated	NADPH dehydrogenase activity (IDA, ISS)
Biological Process
Manually curated	apoptotic process (IMP)
Cellular Component
Manually curated	colocalizes_with mitochondrion (IDA)
High-throughput	cytoplasm (IDA) mitochondrion (IDA) nucleus (IDA)

Classical genetics
null	resistance to acrolein: decreased resistance to methyl vinyl ketone: decreased
overexpression	apoptosis: decreased reactive oxygen species accumulation: decreased resistance to acrolein: increased resistance to methyl vinyl ketone: increased resistance to hydrogen peroxide: increased
Large-scale survey
null	anaerobic growth: decreased auxotrophy competitive fitness: decreased dessication resistance: decreased haploinsufficient resistance to acrolein: decreased resistance to benzo[a]pyrene: decreased respiratory growth: decreased rate vacuolar morphology: abnormal vegetative growth: abnormal viable
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	85 total interaction(s) for 72 unique genes/features.
Physical Interactions	Affinity Capture-MS: 27 Affinity Capture-RNA: 4 Co-fractionation: 1 PCA: 1 Protein-peptide: 2 Reconstituted Complex: 1
Genetic Interactions	Negative Genetic: 44 Phenotypic Suppression: 1 Positive Genetic: 4
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:462502 to 463704 | ORF Map | GBrowse
Last Update	Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1203 462502..463704 2005-11-07 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001222