STB5/YHR178W Summary Help

Standard Name STB5 1
Systematic Name YHR178W
Feature Type ORF, Verified
Description Transcription factor; involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro (1, 2, 3)
Name Description Sin Three Binding protein 1
Chromosomal Location
ChrVIII:459299 to 461530 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All STB5 GO evidence and references
  View Computational GO annotations for STB5
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 22 genes
Regulators 7 genes
Resources
Classical genetics
null
overexpression
Large-scale survey
null
repressible
Resources
259 total interaction(s) for 225 unique genes/features.
Physical Interactions
  • Affinity Capture-Western: 2
  • Reconstituted Complex: 1
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 1
  • Negative Genetic: 174
  • Positive Genetic: 45
  • Synthetic Growth Defect: 21
  • Synthetic Lethality: 11

Resources
Expression Summary
histogram
Resources
Length (a.a.) 743
Molecular Weight (Da) 83,472
Isoelectric Point (pI) 8.48
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:459299 to 461530 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..2232 459299..461530 2005-11-07 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001221
References cited on this page View Complete Literature Guide for STB5
1) Kasten MM and Stillman DJ  (1997) Identification of the Saccharomyces cerevisiae genes STB1-STB5 encoding Sin3p binding proteins. Mol Gen Genet 256(4):376-86
2) Akache B, et al.  (2004) Complex interplay among regulators of drug resistance genes in Saccharomyces cerevisiae. J Biol Chem 279(27):27855-60
3) Larochelle M, et al.  (2006) Oxidative stress-activated zinc cluster protein Stb5 has dual activator/repressor functions required for pentose phosphate pathway regulation and NADPH production. Mol Cell Biol 26(17):6690-701
4) Akache B and Turcotte B  (2002) New regulators of drug sensitivity in the family of yeast zinc cluster proteins. J Biol Chem 277(24):21254-60
5) Harbison CT, et al.  (2004) Transcriptional regulatory code of a eukaryotic genome. Nature 431(7004):99-104
6) Badis G, et al.  (2008) A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Mol Cell 32(6):878-87