SPC97/YHR172W Summary

SPC97 BASIC INFORMATION

Standard Name	SPC97
Systematic Name	YHR172W
Feature Type	ORF, Verified
Description	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque (1, 2)
Name Description	Spindle Pole Component

GO Annotations	All SPC97 GO evidence and references
	View Computational GO annotations for SPC97
Molecular Function
Manually curated	structural constituent of cytoskeleton (IPI)
Biological Process
Manually curated	microtubule nucleation (TAS)
Cellular Component
Manually curated	gamma-tubulin small complex, spindle pole body (IPI) inner plaque of spindle pole body (IDA) outer plaque of spindle pole body (IDA)

Mutant Phenotype	All SPC97 Phenotype details and references
Classical genetics
overexpression	cell cycle progression in M phase: abnormal chromosome segregation: abnormal cytoskeleton morphology: abnormal nuclear morphology: abnormal position of spindle pole body: normal spindle morphology: abnormal
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable
overexpression	cell cycle progression: abnormal
repressible	cell cycle progression in G2 phase: abnormal

Interactions	SPC97 All interactions details and references
	76 total interaction(s) for 14 unique genes/features.
Physical Interactions	Affinity Capture-MS: 14 Affinity Capture-Western: 26 Co-purification: 3 FRET: 7 Reconstituted Complex: 4 Two-hybrid: 11
Genetic Interactions	Dosage Lethality: 1 Dosage Rescue: 4 Synthetic Growth Defect: 2 Synthetic Lethality: 4

Sequence Information

ChrVIII:448335 to 450806 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..2472	448335..450806	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001215

SPC97 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for SPC97

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SPC97]

1)	Nguyen T, et al. (1998) A genetic analysis of interactions with Spc110p reveals distinct functions of Spc97p and Spc98p, components of the yeast gamma-tubulin complex. Mol Biol Cell 9(8):2201-16
2)	Knop M, et al. (1997) The spindle pole body component Spc97p interacts with the gamma-tubulin of Saccharomyces cerevisiae and functions in microtubule organization and spindle pole body duplication. EMBO J 16(7):1550-64

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