Standard Name	NMD3 1
Systematic Name	YHR170W
Alias	SRC5
Feature Type	ORF, Verified
Description	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex (2, 3)
Name Description	Nonsense-Mediated mRNA Decay 1

Chromosomal Location	ChrVIII:443828 to 445384 | ORF Map | GBrowse

	View Computational GO annotations for NMD3
Molecular Function
Manually curated	ribosomal large subunit binding (IDA)
Biological Process
Manually curated	ribosomal large subunit export from nucleus (IGI, IMP)
Cellular Component
Manually curated	cytosol (IDA) colocalizes_with cytosolic large ribosomal subunit (IDA)

Classical genetics
conditional	heat sensitivity: increased 60S ribosomal subunit accumulation: decreased
dominant negative	nuclear export: decreased vegetative growth: arrested
null	inviable vegetative growth: absent
reduction of function	nuclear export: decreased
Large-scale survey
null	competitive fitness: decreased haploinsufficient inviable starvation resistance: decreased
reduction of function	competitive fitness: increased
Resources	PROPHECY | PhenoM | SCMD | ScreenTroll | Yeast Fitness Database

	145 total interaction(s) for 64 unique genes/features.
Physical Interactions	Affinity Capture-MS: 48 Affinity Capture-RNA: 1 Affinity Capture-Western: 53 Co-fractionation: 1 Co-purification: 4 PCA: 2 Reconstituted Complex: 2 Two-hybrid: 3
Genetic Interactions	Dosage Rescue: 8 Negative Genetic: 4 Phenotypic Suppression: 2 Synthetic Growth Defect: 2 Synthetic Lethality: 10 Synthetic Rescue: 5
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | AspGD Homologs | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:443828 to 445384 | ORF Map | GBrowse
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..1557 443828..445384 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FL100 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001213