NMD3/YHR170W Summary Help

Standard Name NMD3 1
Systematic Name YHR170W
Alias SRC5
Feature Type ORF, Verified
Description Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex (2, 3)
Name Description Nonsense-Mediated mRNA Decay 1
Chromosomal Location
ChrVIII:443828 to 445384 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NMD3 GO evidence and references
  View Computational GO annotations for NMD3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 5 genes
Resources
Classical genetics
conditional
dominant negative
null
reduction of function
Large-scale survey
null
reduction of function
Resources
150 total interaction(s) for 65 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 51
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 54
  • Co-fractionation: 1
  • Co-purification: 4
  • PCA: 2
  • Reconstituted Complex: 2
  • Two-hybrid: 3

Genetic Interactions
  • Dosage Rescue: 8
  • Negative Genetic: 4
  • Phenotypic Suppression: 2
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 10
  • Synthetic Rescue: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 518
Molecular Weight (Da) 59,095
Isoelectric Point (pI) 5.21
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:443828 to 445384 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1557 443828..445384 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001213
References cited on this page View Complete Literature Guide for NMD3
1) He F and Jacobson A  (1995) Identification of a novel component of the nonsense-mediated mRNA decay pathway by use of an interacting protein screen. Genes Dev 9(4):437-54
2) Ho JH and Johnson AW  (1999) NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae. Mol Cell Biol 19(3):2389-99
3) Ho JH, et al.  (2000) Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunit. J Cell Biol 151(5):1057-66