Standard Name	KEL1 1
Systematic Name	YHR158C
Feature Type	ORF, Verified
Description	Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate; KEL1 has a paralog, KEL2, that arose from the whole genome duplication (1, 2, 3)
Name Description	KELch repeat 1

Chromosomal Location	ChrVIII:417179 to 413685 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	cell morphogenesis (TAS) cytogamy (IGI, IMP, IPI) negative regulation of exit from mitosis (IMP, IPI) plasma membrane fusion (TAS) regulation of cell shape (IMP)
Cellular Component
Manually curated	cellular bud neck (IDA) cellular bud tip (IDA) mating projection tip (IDA)
High-throughput	cytoplasm (IDA) mating projection tip (IDA)

Classical genetics
overexpression	budding: abnormal cell cycle progression in G1 phase: abnormal cellular morphology: abnormal
Large-scale survey
null	UV resistance: decreased bud morphology: abnormal cell size: decreased competitive fitness: decreased filamentous growth: decreased invasive growth: absent oxidative stress resistance: decreased resistance to bleomycin: increased resistance to hydroxyurea: increased resistance to methyl methanesulfonate: decreased resistance to cycloheximide: decreased resistance to caffeine: decreased resistance to tunicamycin: decreased resistance to 4-nitroquinoline N-oxide: decreased viable
overexpression	vegetative growth: decreased rate vegetative growth: decreased
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	150 total interaction(s) for 103 unique genes/features.
Physical Interactions	Affinity Capture-MS: 30 Affinity Capture-RNA: 1 Affinity Capture-Western: 9 Biochemical Activity: 3 PCA: 7 Two-hybrid: 53
Genetic Interactions	Dosage Growth Defect: 4 Negative Genetic: 14 Phenotypic Enhancement: 9 Phenotypic Suppression: 10 Positive Genetic: 4 Synthetic Growth Defect: 4 Synthetic Rescue: 2
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DIP | DRYGIN | GeneMANIA | InterologFinder | YeastRC Two-Hybrid

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP | YeastRC
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:417179 to 413685 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..3495 417179..413685 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CBS7960 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain CLIB324 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain Y10 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001201