RTT107/YHR154W Summary Help

RTT107 BASIC INFORMATION

Standard Name RTT107 1
Systematic Name YHR154W
Alias ESC4 2
Feature Type ORF, Verified
Description Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition (1, 3, 4, 5)
Name Description Regulator of Ty1 Transposition 1
GO Annotations All RTT107 GO evidence and references
    View Computational GO annotations for RTT107
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Mutant Phenotype All RTT107 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions RTT107 All interactions details and references
180 total interaction(s) for 122 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 16
  • Affinity Capture-Western: 4
  • PCA: 1
  • Reconstituted Complex: 2
  • Two-hybrid: 15
Genetic Interactions
  • Phenotypic Enhancement: 37
  • Phenotypic Suppression: 9
  • Synthetic Growth Defect: 69
  • Synthetic Lethality: 27
Sequence Information
ChrVIII:402969 to 406181 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3213 402969..406181 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001197

RTT107 RESOURCES

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SGD ORF mapGBrowse
SGD ORF map
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  • Functional Analysis

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Expression Summary histogram

ADDITIONAL INFORMATION for RTT107

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for RTT107]

1) Scholes DT, et al.  (2001) Multiple regulators of Ty1 transposition in Saccharomyces cerevisiae have conserved roles in genome maintenance. Genetics 159(4):1449-65
2) Andrulis ED, et al.  (2004) One-hybrid screens at the Saccharomyces cerevisiae HMR locus identify novel transcriptional silencing factors. Genetics 166(1):631-5
3) Rouse J  (2004) Esc4p, a new target of Mec1p (ATR), promotes resumption of DNA synthesis after DNA damage. EMBO J 23(5):1188-97
4) Baldwin EL, et al.  (2005) Mms22p protects Saccharomyces cerevisiae from DNA damage induced by topoisomerase II. Nucleic Acids Res 33(3):1021-30
5) Roberts TM, et al.  (2006) Slx4 regulates DNA damage checkpoint-dependent phosphorylation of the BRCT domain protein Rtt107/Esc4. Mol Biol Cell 17(1):539-48