WSS1/YHR134W Summary Help

Standard Name WSS1 1
Systematic Name YHR134W
Feature Type ORF, Verified
Description Sumoylated protein localizing to the nuclear periphery of mother cells; localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response (1, 2, 3, 4, 5)
Name Description Weak Suppressor of Smt3 1
Chromosomal Location
ChrVIII:371749 to 372558 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All WSS1 GO evidence and references
  View Computational GO annotations for WSS1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 67 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
86 total interaction(s) for 59 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 5
  • Biochemical Activity: 2
  • Two-hybrid: 15

Genetic Interactions
  • Dosage Rescue: 5
  • Negative Genetic: 20
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 24
  • Synthetic Lethality: 9
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 269
Molecular Weight (Da) 30,627
Isoelectric Point (pI) 9.16
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:371749 to 372558 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..810 371749..372558 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001176
References cited on this page View Complete Literature Guide for WSS1
1) Biggins S, et al.  (2001) Genes involved in sister chromatid separation and segregation in the budding yeast Saccharomyces cerevisiae. Genetics 159(2):453-70
2) Hannich JT, et al.  (2005) Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae. J Biol Chem 280(6):4102-10
3) O'Neill BM, et al.  (2004) Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. Nucleic Acids Res 32(22):6519-30
4) Birrell GW, et al.  (2001) A genome-wide screen in Saccharomyces cerevisiae for genes affecting UV radiation sensitivity. Proc Natl Acad Sci U S A 98(22):12608-13
5) van Heusden GP and Steensma HY  (2008) The Saccharomyces cerevisiae Wss1 protein is only present in mother cells. FEMS Microbiol Lett 282(1):100-4