NDT80/YHR124W Summary Help

Standard Name NDT80 1
Systematic Name YHR124W
Feature Type ORF, Verified
Description Meiosis-specific transcription factor; required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) (1, 2, 3)
Name Description Non-DiTyrosine 1
Chromosomal Location
ChrVIII:356561 to 358444 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All NDT80 GO evidence and references
  View Computational GO annotations for NDT80
Molecular Function
Manually curated
High-throughput
Biological Process
Manually curated
Cellular Component
Manually curated
Targets 6 genes
Regulators 2 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
Resources
59 total interaction(s) for 50 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 4
  • Affinity Capture-RNA: 1
  • Biochemical Activity: 4

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 14
  • Phenotypic Enhancement: 13
  • Phenotypic Suppression: 10
  • Positive Genetic: 5
  • Synthetic Growth Defect: 1
  • Synthetic Lethality: 2
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 627
Molecular Weight (Da) 71,479
Isoelectric Point (pI) 6.59
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:356561 to 358444 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1884 356561..358444 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001166
References cited on this page View Complete Literature Guide for NDT80
1) Xu L, et al.  (1995) NDT80, a meiosis-specific gene required for exit from pachytene in Saccharomyces cerevisiae. Mol Cell Biol 15(12):6572-81
2) Hepworth SR, et al.  (1998) NDT80 and the meiotic recombination checkpoint regulate expression of middle sporulation-specific genes in Saccharomyces cerevisiae. Mol Cell Biol 18(10):5750-61
3) Pierce M, et al.  (2003) Sum1 and Ndt80 proteins compete for binding to middle sporulation element sequences that control meiotic gene expression. Mol Cell Biol 23(14):4814-25
4) Zhu C, et al.  (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19(4):556-66