SET1/YHR119W Summary Help

SET1 BASIC INFORMATION

Standard Name SET1 1
Systematic Name YHR119W
Alias YTX1
Feature Type ORF, Verified
Description Histone methyltransferase, subunit of the COMPASS (Set1C) complex which methylates histone H3 on lysine 4; required in transcriptional silencing near telomeres and at the silent mating type loci; contains a SET domain (2, 3, 4, 5, 6)
Name Description SET domain-containing 1
Gene Product Alias KMT2 7
GO Annotations All SET1 GO evidence and references
    View Computational GO annotations for SET1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulatory Role
Regulatory modules predicted: stressResponse ( 547 )
Mutant Phenotype All SET1 Phenotype details and references
Classical genetics
null
Large-scale survey
null
Interactions SET1 All interactions details and references
151 total interaction(s) for 62 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 73
  • Affinity Capture-Western: 13
  • Biochemical Activity: 4
  • Co-fractionation: 1
  • Co-localization: 2
  • Co-purification: 10
  • Protein-RNA: 4
  • Reconstituted Complex: 3
  • Two-hybrid: 6
Genetic Interactions
  • Dosage Rescue: 1
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 3
  • Synthetic Growth Defect: 4
  • Synthetic Lethality: 7
  • Synthetic Rescue: 13
Sequence Information
ChrVIII:346046 to 349288 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..3243 346046..349288 2005-11-07 1996-07-31
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001161

SET1 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for SET1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for SET1]

1) Nislow C, et al.  (1997) SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes. Mol Biol Cell 8(12):2421-36
2) Miller T, et al.  (2001) COMPASS: a complex of proteins associated with a trithorax-related SET domain protein. Proc Natl Acad Sci U S A 98(23):12902-7
3) Krogan NJ, et al.  (2002) COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression. J Biol Chem 277(13):10753-5
4) Dover J, et al.  (2002) Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277(32):28368-71
5) Boa S, et al.  (2003) Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression. Yeast 20(9):827-35
6) Cheng H, et al.  (2004) The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3. Mol Cell Biol 24(7):2932-43
7) Allis CD, et al.  (2007) New nomenclature for chromatin-modifying enzymes. Cell 131(4):633-6