COX23/YHR116W Summary Help

Standard Name COX23 1
Systematic Name YHR116W
Feature Type ORF, Verified
Description Protein that functions in mitochondrial copper homeostasis; mitochondrial intermembrane space protein; essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs (1, 2)
Name Description Cytochrome OXidase 1
Chromosomal Location
ChrVIII:341665 to 342120 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All COX23 GO evidence and references
  View Computational GO annotations for COX23
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 11 genes
Resources
Classical genetics
null
Large-scale survey
null
Resources
153 total interaction(s) for 111 unique genes/features.
Physical Interactions
  • Affinity Capture-RNA: 3
  • Biochemical Activity: 1
  • PCA: 1

Genetic Interactions
  • Dosage Growth Defect: 1
  • Negative Genetic: 124
  • Positive Genetic: 17
  • Synthetic Growth Defect: 2
  • Synthetic Lethality: 2
  • Synthetic Rescue: 2

Resources
Expression Summary
histogram
Resources
Length (a.a.) 151
Molecular Weight (Da) 17,318
Isoelectric Point (pI) 7.74
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:341665 to 342120 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..456 341665..342120 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001158
References cited on this page View Complete Literature Guide for COX23
1) Barros MH, et al.  (2004) COX23, a homologue of COX17, is required for cytochrome oxidase assembly. J Biol Chem 279(30):31943-7
2) Longen S, et al.  (2009) Systematic analysis of the twin cx(9)c protein family. J Mol Biol 393(2):356-68