GGA2/YHR108W Summary Help

Standard Name GGA2 1
Systematic Name YHR108W
Feature Type ORF, Verified
Description Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin; GGA2 has a paralog, GGA1, that arose from the whole genome duplication (1, 2, 3)
Name Description Golgi-localized, Gamma-adaptin ear homology, Arf-binding protein 1
Chromosomal Location
ChrVIII:328303 to 330060 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GGA2 GO evidence and references
  View Computational GO annotations for GGA2
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 4 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
unspecified
Resources
154 total interaction(s) for 84 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 28
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 13
  • Co-purification: 2
  • PCA: 4
  • Reconstituted Complex: 9
  • Two-hybrid: 13

Genetic Interactions
  • Negative Genetic: 52
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 2
  • Positive Genetic: 1
  • Synthetic Growth Defect: 13
  • Synthetic Lethality: 6
  • Synthetic Rescue: 3

Resources
Expression Summary
histogram
Resources
Length (a.a.) 585
Molecular Weight (Da) 64,346
Isoelectric Point (pI) 6.46
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:328303 to 330060 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1758 328303..330060 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001150
References cited on this page View Complete Literature Guide for GGA2
1) Zhdankina O, et al.  (2001) Yeast GGA proteins interact with GTP-bound Arf and facilitate transport through the Golgi. Yeast 18(1):1-18
2) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3) Demmel L, et al.  (2008) The clathrin adaptor Gga2p is a phosphatidylinositol 4-phosphate effector at the Golgi exit. Mol Biol Cell 19(5):1991-2002