GRE3/YHR104W Summary Help

Standard Name GRE3 1
Systematic Name YHR104W
Feature Type ORF, Verified
Description Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress (1, 2, 3, 4, 5, 6, 7)
Name Description Genes de Respuesta a Estres (stress responsive genes) 1
Chromosomal Location
ChrVIII:323409 to 324392 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All GRE3 GO evidence and references
  View Computational GO annotations for GRE3
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
High-throughput
Regulators 9 genes
Resources
Pathways
Classical genetics
null
overexpression
Large-scale survey
null
overexpression
repressible
Resources
147 total interaction(s) for 131 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 9
  • Affinity Capture-RNA: 2
  • Affinity Capture-Western: 1
  • Biochemical Activity: 1
  • PCA: 5
  • Reconstituted Complex: 3

Genetic Interactions
  • Dosage Growth Defect: 2
  • Dosage Rescue: 5
  • Negative Genetic: 84
  • Phenotypic Enhancement: 4
  • Positive Genetic: 26
  • Synthetic Growth Defect: 5

Resources
Expression Summary
histogram
Resources
Length (a.a.) 327
Molecular Weight (Da) 37,118
Isoelectric Point (pI) 7.07
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:323409 to 324392 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..984 323409..324392 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001146
References cited on this page View Complete Literature Guide for GRE3
1) Garay-Arroyo A and Covarrubias AA  (1999) Three genes whose expression is induced by stress in Saccharomyces cerevisiae. Yeast 15(10A):879-92
2) Petrash JM, et al.  (2001) Functional genomic studies of aldo-keto reductases. Chem Biol Interact 130-132(1-3):673-83
3) Aguilera J and Prieto JA  (2001) The Saccharomyces cerevisiae aldose reductase is implied in the metabolism of methylglyoxal in response to stress conditions. Curr Genet 39(5-6):273-83
4) Traff KL, et al.  (2001) Deletion of the GRE3 aldose reductase gene and its influence on xylose metabolism in recombinant strains of Saccharomyces cerevisiae expressing the xylA and XKS1 genes. Appl Environ Microbiol 67(12):5668-74
5) Traff KL, et al.  (2002) Putative xylose and arabinose reductases in Saccharomyces cerevisiae. Yeast 19(14):1233-41
6) Masuda CA, et al.  (2008) Overexpression of the aldose reductase GRE3 suppresses lithium-induced galactose toxicity in Saccharomyces cerevisiae. FEMS Yeast Res 8(8):1245-53
7) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76