KIC1/YHR102W Summary Help

Standard Name KIC1 1
Systematic Name YHR102W
Alias NRK1
Feature Type ORF, Verified
Description Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis (1, 2)
Name Description Kinase that Interacts with Cdc31p 1
Chromosomal Location
ChrVIII:316572 to 319814 | ORF Map | GBrowse
Gbrowse
Gene Ontology Annotations All KIC1 GO evidence and references
  View Computational GO annotations for KIC1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 106 genes
Resources
Classical genetics
null
unspecified
Large-scale survey
null
overexpression
repressible
Resources
53 total interaction(s) for 32 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 19
  • Affinity Capture-Western: 3
  • PCA: 2
  • Protein-RNA: 1
  • Two-hybrid: 9

Genetic Interactions
  • Dosage Rescue: 5
  • Phenotypic Enhancement: 5
  • Synthetic Growth Defect: 6
  • Synthetic Lethality: 2
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 1,080
Molecular Weight (Da) 117,060
Isoelectric Point (pI) 8.08
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:316572 to 319814 | ORF Map | GBrowse
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..3243 316572..319814 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | E.C. | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001144
References cited on this page View Complete Literature Guide for KIC1
1) Sullivan DS, et al.  (1998) The yeast centrin, cdc31p, and the interacting protein kinase, Kic1p, are required for cell integrity. J Cell Biol 143(3):751-65
2) Nelson B, et al.  (2003) RAM: a conserved signaling network that regulates Ace2p transcriptional activity and polarized morphogenesis. Mol Biol Cell 14(9):3782-803