BIG1/YHR101C Summary Help

Standard Name BIG1 1
Systematic Name YHR101C
Feature Type ORF, Verified
Description Integral membrane protein of the endoplasmic reticulum; required for normal content of cell wall beta-1,6-glucan (2)
Name Description Bad In Glucose 1
Chromosomal Location
ChrVIII:315968 to 314874 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Gene Ontology Annotations All BIG1 GO evidence and references
  View Computational GO annotations for BIG1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
Regulators 6 genes
Resources
Classical genetics
conditional
null
Large-scale survey
conditional
null
reduction of function
repressible
Resources
126 total interaction(s) for 70 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 3
  • Affinity Capture-RNA: 1
  • Affinity Capture-Western: 1

Genetic Interactions
  • Dosage Rescue: 2
  • Negative Genetic: 116
  • Phenotypic Enhancement: 1
  • Synthetic Lethality: 1
  • Synthetic Rescue: 1

Resources
Expression Summary
histogram
Resources
Length (a.a.) 335
Molecular Weight (Da) 39,068
Isoelectric Point (pI) 5.04
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:315968 to 314874 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..110 315968..315859 2011-02-03 1996-07-31
Intron 111..197 315858..315772 2011-02-03 1996-07-31
CDS 198..1095 315771..314874 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB
Primary SGDIDS000001143
References cited on this page View Complete Literature Guide for BIG1
1) Bickle M, et al.  (1998) Cell wall integrity modulates RHO1 activity via the exchange factor ROM2. EMBO J 17(8):2235-45
2) Azuma M, et al.  (2002) Saccharomyces cerevisiae Big1p, a putative endoplasmic reticulum membrane protein required for normal levels of cell wall beta-1,6-glucan. Yeast 19(9):783-93