Standard Name	BIG1
Systematic Name	YHR101C
Feature Type	ORF, Verified
Description	Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan (1)
Name Description	Bad In Glucose 2

Chromosomal Location	ChrVIII:315968 to 314874 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.

	View Computational GO annotations for BIG1
Molecular Function
Manually curated	molecular_function unknown (ND)
Biological Process
Manually curated	fungal-type cell wall biogenesis (IGI, IMP)
Cellular Component
Manually curated	integral to endoplasmic reticulum membrane (IDA)

Classical genetics
conditional	colony sectoring: increased
null	cell shape: abnormal cell size: abnormal colony size: decreased resistance to hygromycin B: decreased resistance to sodium dodecyl sulfate: decreased vegetative growth: decreased rate viable
Large-scale survey
conditional	heat sensitivity: increased
null	inviable resistance to cycloheximide: decreased starvation resistance: decreased
reduction of function	competitive fitness: increased resistance to methyl methanesulfonate: decreased
repressible	cell cycle progression in G2 phase: abnormal
Resources	PROPHECY | SCMD | ScreenTroll | Yeast Fitness Database

	81 total interaction(s) for 40 unique genes/features.
Physical Interactions	Affinity Capture-MS: 2 Affinity Capture-Western: 1
Genetic Interactions	Dosage Rescue: 2 Negative Genetic: 73 Phenotypic Enhancement: 1 Synthetic Lethality: 1 Synthetic Rescue: 1
Resources	BioGRID | BOND | BioPIXIE | CYC2008 (complexes) | Complexome | DRYGIN | GeneMANIA | InterologFinder

Resources	Expression Summary | Cell cycle and metabolic oscillation | Cell cycle transcript profile | Cyclebase | Genevestigator | GermOnline | SPELL | YMGV | YeastFunc

Localization	YeastRC | Organelle DB (UMich) | YPL+ | YeastGFP
Phosphorylation	PhosphoGRID | PhosphoPep Database
Structure	GPMDB | SCOP
Homologs	Ashbya (AGD) | CGD Homologs | CandidaDB Homologs | Fungal Orthogroups Repository | P-POD | PDB Homologs | PhylomeDB | YGOB | YOGY

	ChrVIII:315968 to 314874 | ORF Map | GBrowse
	Note: this feature is encoded on the Crick strand.
Last Update	Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details	Relative Coordinates Chromosomal Coordinates Most Recent Updates Coordinates Sequence CDS 1..110 315968..315859 2011-02-03 1996-07-31 Intron 111..197 315858..315772 2011-02-03 1996-07-31 CDS 198..1095 315771..314874 2011-02-03 1996-07-31
Retrieve sequences	S.c. Reference Strain S288C S.c. Strain AWRI1631 S.c. Strain AWRI796 S.c. Strain BY4741 S.c. Strain BY4742 S.c. Strain CEN.PK113-7D S.c. Strain CLIB215 S.c. Strain EC1118 S.c. Strain EC9-8 S.c. Strain FostersB S.c. Strain FostersO S.c. Strain JAY291 S.c. Strain Kyokai7 S.c. Strain LalvinQA23 S.c. Strain PW5 S.c. Strain RM11-1a S.c. Strain Sigma1278b S.c. Strain T7 S.c. Strain T73 S.c. Strain UC5 S.c. Strain Vin13 S.c. Strain VL3 S.c. Strain W303 S.c. Strain YJM269 S.c. Strain YJM789 S.c. Strain YPS163 S.c. Strain ZTW1 ORF Genomic DNA ORF Translation Coding sequence (CDS) Intron (111 - 197)

S288C only	BLASTP | ATCC/WashU Clones | BLASTN | Design Primers | Restriction Fragment Map | Restriction Fragment Sizes | Six-Frame Translation
S288C vs. other species	Fungal Alignment | BLASTN vs. fungi | BLASTP at NCBI | BLASTP vs. fungi | Synteny Viewer
S288C vs. other strains	Strain Alignment

External Links	All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | UniProtKB

Primary SGDID	S000001143