TRA1/YHR099W Summary Help

TRA1 BASIC INFORMATION

Standard Name TRA1 1, 2
Systematic Name YHR099W
Feature Type ORF, Verified
Description Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation (1, 2, 3, 4)
Name Description similar to human TRAAP 1, 2
GO Annotations All TRA1 GO evidence and references
    View Computational GO annotations for TRA1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Mutant Phenotype All TRA1 Phenotype details and references
Classical genetics
conditional
null
Large-scale survey
null
Interactions TRA1 All interactions details and references
249 total interaction(s) for 161 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 88
  • Affinity Capture-Western: 37
  • Co-fractionation: 2
  • Co-purification: 6
  • FRET: 1
  • Two-hybrid: 2
Genetic Interactions
  • Dosage Rescue: 1
  • Synthetic Growth Defect: 101
  • Synthetic Lethality: 11
Sequence Information
ChrVIII:302764 to 313998 | ORF Map | GBrowse
Gbrowse
Last Update Coordinates: 2005-11-07 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates		 Chromosomal
Coordinates		 Most Recent Updates
Coordinates Sequence
CDS 1..11235 302764..313998 2005-11-07 1996-07-31
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | UniProtKB
Primary SGDIDS000001141

TRA1 RESOURCES

Click on map for expanded view
SGD ORF mapGBrowse
SGD ORF map
 GBrowse
  • Literature
  • Retrieve Sequences
  • Sequence Analysis Tools
  • Protein Info & Structure
  • Localization Resources
  • Interactions
  • Phenotype Resources
  • Maps & Displays
  • Comparison Resources
  • Functional Analysis

Click on histogram for expression summary
Expression Summary histogram

ADDITIONAL INFORMATION for TRA1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for TRA1]

1) Grant PA, et al.  (1998) The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2(6):863-7
2) Saleh A, et al.  (1998) Tra1p is a component of the yeast Ada.Spt transcriptional regulatory complexes. J Biol Chem 273(41):26559-65
3) Brown CE, et al.  (2001) Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science 292(5525):2333-7
4) Bhaumik SR, et al.  (2004) In vivo target of a transcriptional activator revealed by fluorescence resonance energy transfer. Genes Dev 18(3):333-43