HXT1/YHR094C Summary Help

Standard Name HXT1 1
Systematic Name YHR094C
Alias HOR4 2
Feature Type ORF, Verified
Description Low-affinity glucose transporter of the major facilitator superfamily; expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting; HXT1 has a paralog, HXT6, what arose from the whole genome duplication (3, 4, 5)
Name Description HeXose Transporter 1
Chromosomal Location
ChrVIII:292625 to 290913 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
Gbrowse
Genetic position: 66.54 cM
Gene Ontology Annotations All HXT1 GO evidence and references
  View Computational GO annotations for HXT1
Molecular Function
Manually curated
Biological Process
Manually curated
Cellular Component
Manually curated
High-throughput
Regulators 7 genes
Resources
Classical genetics
null
Large-scale survey
null
overexpression
Resources
120 total interaction(s) for 100 unique genes/features.
Physical Interactions
  • Affinity Capture-MS: 8
  • Affinity Capture-RNA: 1
  • Co-fractionation: 2
  • PCA: 46
  • Protein-RNA: 1
  • Two-hybrid: 1

Genetic Interactions
  • Dosage Lethality: 1
  • Dosage Rescue: 7
  • Negative Genetic: 31
  • Phenotypic Enhancement: 7
  • Phenotypic Suppression: 2
  • Positive Genetic: 7
  • Synthetic Rescue: 6

Resources
Expression Summary
histogram
Resources
Length (a.a.) 570
Molecular Weight (Da) 63,261
Isoelectric Point (pI) 7.33
Localization
Phosphorylation PhosphoGRID | PhosphoPep Database
Structure
Homologs
sequence information
ChrVIII:292625 to 290913 | ORF Map | GBrowse
Note: this feature is encoded on the Crick strand.
SGD ORF map
Genetic position: 66.54 cM
Last Update Coordinates: 2011-02-03 | Sequence: 1996-07-31
Subfeature details
Relative
Coordinates
Chromosomal
Coordinates
Most Recent Updates
Coordinates Sequence
CDS 1..1713 292625..290913 2011-02-03 1996-07-31
Retrieve sequences
Analyze Sequence
S288C only
S288C vs. other species
S288C vs. other strains
Resources
External Links All Associated Seq | Entrez Gene | Entrez RefSeq Protein | MIPS | Search all NCBI (Entrez) | TCDB | UniProtKB
Primary SGDIDS000001136
References cited on this page View Complete Literature Guide for HXT1
1) Lewis DA and Bisson LF  (1991) The HXT1 gene product of Saccharomyces cerevisiae is a new member of the family of hexose transporters. Mol Cell Biol 11(7):3804-13
2) Hirayama T, et al.  (1995) Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae. Mol Gen Genet 249(2):127-38
3) Rodriguez A, et al.  (2001) The hexokinase 2 protein regulates the expression of the GLK1, HXK1 and HXK2 genes of Saccharomyces cerevisiae. Biochem J 355(Pt 3):625-31
4) Mosley AL, et al.  (2003) Glucose-mediated phosphorylation converts the transcription factor Rgt1 from a repressor to an activator. J Biol Chem 278(12):10322-7
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61