HXT1/YHR094C Summary

HXT1 BASIC INFORMATION

Standard Name	HXT1 1
Systematic Name	YHR094C
Alias	HOR4 2
Feature Type	ORF, Verified
Description	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting (3, 4)
Name Description	HeXose Transporter 1

GO Annotations	All HXT1 GO evidence and references
	View Computational GO annotations for HXT1
Molecular Function
Manually curated	fructose transmembrane transporter activity (IMP) galactose transmembrane transporter activity (TAS) glucose transmembrane transporter activity (TAS) mannose transmembrane transporter activity (TAS) pentose transmembrane transporter activity (IMP)
Biological Process
Manually curated	glucose transport (IMP) mannose transport (IMP)
Cellular Component
Manually curated	membrane fraction (IDA) plasma membrane (IDA)

Mutant Phenotype	All HXT1 Phenotype details and references
Classical genetics
null	resistance to quinine: increased small molecule transport: decreased viable
Large-scale survey
null	viable
overexpression	vegetative growth: decreased

Interactions	HXT1 All interactions details and references
	74 total interaction(s) for 63 unique genes/features.
Physical Interactions	Affinity Capture-MS: 3 Co-fractionation: 2 PCA: 38 Protein-RNA: 1 Two-hybrid: 9
Genetic Interactions	Dosage Rescue: 7 Phenotypic Enhancement: 7 Phenotypic Suppression: 3 Synthetic Rescue: 4

Sequence Information

ChrVIII:292628 to 290916 | |

Note: this feature is encoded on the Crick strand.

Genetic position: 66.54 cM

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1713	292628..290916	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| TCDB \| UniProtKB

Primary SGDID	S000001136

HXT1 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HXT1

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HXT1]

1)	Lewis DA and Bisson LF (1991) The HXT1 gene product of Saccharomyces cerevisiae is a new member of the family of hexose transporters. Mol Cell Biol 11(7):3804-13
2)	Hirayama T, et al. (1995) Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae. Mol Gen Genet 249(2):127-38
3)	Rodriguez A, et al. (2001) The hexokinase 2 protein regulates the expression of the GLK1, HXK1 and HXK2 genes of Saccharomyces cerevisiae. Biochem J 355(Pt 3):625-31
4)	Mosley AL, et al. (2003) Glucose-mediated phosphorylation converts the transcription factor Rgt1 from a repressor to an activator. J Biol Chem 278(12):10322-7

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