HXT4/YHR092C Summary

HXT4 BASIC INFORMATION

Standard Name	HXT4
Systematic Name	YHR092C
Alias	LGT1 , RAG1
Feature Type	ORF, Verified
Description	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose (1, 2)
Name Description	HeXose Transporter

GO Annotations	All HXT4 GO evidence and references
	View Computational GO annotations for HXT4
Molecular Function
Manually curated	fructose transmembrane transporter activity (TAS) glucose transmembrane transporter activity (IDA, TAS) mannose transmembrane transporter activity (TAS) pentose transmembrane transporter activity (IMP)
Biological Process
Manually curated	hexose transport (TAS)
Cellular Component
Manually curated	membrane fraction (IDA) plasma membrane (ISS)

Mutant Phenotype	All HXT4 Phenotype details and references
Classical genetics
null	resistance to quinine: increased
overexpression	small molecule transport: increased
Large-scale survey
null	filamentous growth: decreased hyperosmotic stress resistance: decreased invasive growth: absent resistance to propan-1-ol: decreased viable

Interactions	HXT4 All interactions details and references
	18 total interaction(s) for 18 unique genes/features.
Physical Interactions	Affinity Capture-RNA: 1 Co-fractionation: 2 Two-hybrid: 2
Genetic Interactions	Dosage Rescue: 3 Phenotypic Enhancement: 6 Synthetic Growth Defect: 3 Synthetic Lethality: 1

Sequence Information

ChrVIII:288814 to 287132 | |

Note: this feature is encoded on the Crick strand.

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..1683	288814..287132	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| TCDB \| UniProtKB

Primary SGDID	S000001134

HXT4 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for HXT4

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for HXT4]

1)	Ozcan S and Johnston M (1999) Function and regulation of yeast hexose transporters. Microbiol Mol Biol Rev 63(3):554-69
2)	Ozcan S and Johnston M (1995) Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Mol Cell Biol 15(3):1564-72

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