PCL5/YHR071W Summary

PCL5 BASIC INFORMATION

Standard Name	PCL5
Systematic Name	YHR071W
Feature Type	ORF, Verified
Description	Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity (1, 2, 3)
Name Description	Pho85 CycLin 1

GO Annotations	All PCL5 GO evidence and references
	View Computational GO annotations for PCL5
Molecular Function
Manually curated	cyclin-dependent protein kinase regulator activity (IDA)
Biological Process
Manually curated	negative regulation of transcription factor activity (IMP) regulation of protein stability (IMP)
Cellular Component
Manually curated	cyclin-dependent protein kinase holoenzyme complex (IPI) nucleus (IDA)

Mutant Phenotype	All PCL5 Phenotype details and references
Classical genetics
reduction of function	resistance to amitrole: decreased

Interactions	PCL5 All interactions details and references
	9 total interaction(s) for 6 unique genes/features.
Physical Interactions	Affinity Capture-Western: 2 Biochemical Activity: 1 Reconstituted Complex: 1 Two-hybrid: 1
Genetic Interactions	Phenotypic Enhancement: 1 Phenotypic Suppression: 2 Synthetic Rescue: 1

Sequence Information

ChrVIII:237006 to 237695 | |

Last Update

Coordinates: 2005-11-07 | Sequence: 1996-07-31

Subfeature details

	Relative Coordinates	Chromosomal Coordinates	Most Recent Updates
	Relative Coordinates	Chromosomal Coordinates	Coordinates	Sequence
CDS	1..690	237006..237695	2005-11-07	1996-07-31

External Links	All Associated Seq \| Entrez Gene \| Entrez RefSeq Protein \| MIPS \| UniProtKB

Primary SGDID	S000001113

PCL5 RESOURCES

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SGD ORF map	GBrowse

Click on histogram for expression summary
Expression Summary

ADDITIONAL INFORMATION for PCL5

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for PCL5]

1)	Measday V, et al. (1997) A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Mol Cell Biol 17(3):1212-23
2)	Shemer R, et al. (2002) Regulation of the transcription factor Gcn4 by Pho85 cyclin PCL5. Mol Cell Biol 22(15):5395-404
3)	Aviram S, et al. (2008) Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation. Mol Cell Biol 28(22):6858-69

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